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中华普外科手术学杂志(电子版) ›› 2025, Vol. 19 ›› Issue (05) : 574 -578. doi: 10.3877/cma.j.issn.1674-3946.2025.05.025

所属专题: 文献

综述

胰头区恶性肿瘤外科手术预后现状及相关因素的研究进展
张聪(), 李成   
  1. 610041 成都,四川大学华西医院胰腺外科
  • 收稿日期:2024-12-04 出版日期:2025-10-26
  • 通信作者: 张聪

Research progress on the prognosis status and related factors of surgical treatment for malignant tumors in the pancreatic head region

Cong Zhang(), Cheng Li   

  1. Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan Province 610041, China
  • Received:2024-12-04 Published:2025-10-26
  • Corresponding author: Cong Zhang
  • Supported by:
    Sichuan Province Science and Technology Plan Project(2024YFHZ0053)
引用本文:

张聪, 李成. 胰头区恶性肿瘤外科手术预后现状及相关因素的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(05): 574-578.

Cong Zhang, Cheng Li. Research progress on the prognosis status and related factors of surgical treatment for malignant tumors in the pancreatic head region[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(05): 574-578.

胰头区恶性肿瘤指起源于胰腺头部及其周边区域的恶性细胞增殖,其发病率逐年上升,最常见类型为胰腺导管腺癌(PDAC)、壶腹癌和远端胆管癌。治疗胰头区恶性肿瘤的外科手术为胰十二指肠切除术(PD)及其改良术式,尽管手术技术进步,但患者长期生存率仍然较低,不同手术方式预后差异及优势尚存争议,且受医生经验和医疗中心手术量影响。影响胰头区恶性肿瘤外科手术预后的主要因素包括病变部位、肿瘤大小、淋巴结转移、血管与神经浸润、切除切缘状态,可根据这些因素制定个性化手术方案和辅助治疗策略,以提高患者生存率和生活质量。本文针对胰头区恶性肿瘤外科手术预后现状及相关因素进行综述,以期为临床实践提供科学依据。

Malignant tumors in the pancreatic head region refer to the malignant cell proliferation originating from the head of the pancreas and its surrounding areas, with an increasing incidence year by year. The most common types are pancreatic ductal adenocarcinoma (PDAC), ampullary carcinoma, and distal bile duct carcinoma. The surgical treatment for malignant tumors in the pancreatic head region is pancreaticoduodenectomy (PD) and its modified procedures. Although surgical techniques have advanced, the long-term survival rate of patients remains low. The prognostic differences and advantages of different surgical approaches are still controversial, and they are affected by the experience of surgeons and the surgical volume of medical centers. The main factors affecting the prognosis of surgical treatment for malignant tumors in the pancreatic head region include the lesion site, tumor size, lymph node metastasis, vascular and nerve invasion, and the status of resection margins. Personalized surgical plans and adjuvant treatment strategies can be formulated based on these factors to improve the survival rate and quality of life of patients. This article reviews the current status of the prognosis of surgical treatment for malignant tumors in the pancreatic head region and related factors, aiming to provide a scientific basis for clinical practice.

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