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中华普外科手术学杂志(电子版) ›› 2025, Vol. 19 ›› Issue (05) : 570 -573. doi: 10.3877/cma.j.issn.1674-3946.2025.05.024

所属专题: 文献

综述

三级淋巴结构在胰腺癌中的研究进展
高峰1, 郝少龙1, 孙浩2, 韩威1,()   
  1. 1101149 北京,首都医科大学附属北京潞河医院普外科
    2101149 北京,首都医科大学附属北京潞河医院中心实验室
  • 收稿日期:2025-03-28 出版日期:2025-10-26
  • 通信作者: 韩威

Research progress of tertiary lymphoid structures in pancreatic cancer

Feng Gao1, Shaolong Hao1, Hao Sun2, Wei Han1,()   

  1. 1Department of General Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
    2Central LAB, the Affiliated Luhe Hospital of Capital Medical University, Beijing 101149, China
  • Received:2025-03-28 Published:2025-10-26
  • Corresponding author: Wei Han
  • Supported by:
    Beijing Natural Science Foundation(7234377)
引用本文:

高峰, 郝少龙, 孙浩, 韩威. 三级淋巴结构在胰腺癌中的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(05): 570-573.

Feng Gao, Shaolong Hao, Hao Sun, Wei Han. Research progress of tertiary lymphoid structures in pancreatic cancer[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(05): 570-573.

胰腺癌(PC)是一种恶性程度高、预后差的恶性肿瘤,其肿瘤微环境(TME)中缺氧和免疫抑制特性导致的化疗耐药性以及免疫逃逸成为治愈率低的重要原因。在肿瘤组织中,淋巴细胞聚集形成有组织的异位淋巴结构,被称为三级淋巴结构(TLSs)。TLSs存在于PC瘤内和瘤周组织中。TLSs在包括PC在内的多种肿瘤中通过抗肿瘤免疫反应发挥作用,与良好预后相关。诱导TLSs形成可促进肿瘤抗原呈递及T细胞和B细胞的成熟分化,强化对肿瘤细胞的识别和杀伤能力,提升抗肿瘤免疫反应。PC中TLSs与肿瘤的发生发展、长期预后及良好治疗反应性相关,为PC的治疗提供了新的策略和视角。本文从TLSs在PC中的形成、抗肿瘤作用及在PC预后与治疗中的应用等方面进行综述,为PC中TLSs的深入研究提供参考。

Pancreatic cancer (PC) is a malignant tumor with high malignancy and poor prognosis. Chemoresistance and immune escape caused by the hypoxic and immunosuppressive characteristics of its tumor microenvironment (TME) have become important reasons for the low cure rate. In tumor tissues, lymphocytes aggregate to form organized ectopic lymphoid structures, known as tertiary lymphoid structures (TLSs). TLSs exist in both intratumoral and peritumoral tissues of PC. TLSs play a role through anti-tumor immune responses in various tumors including PC, and are associated with favorable prognosis. Inducing the formation of TLSs can promote tumor antigen presentation, maturation and differentiation of T and B cells, enhance the ability to recognize and kill tumor cells, and improve anti-tumor immune responses. TLSs in PC are related to tumor occurrence and development, long-term prognosis, and good treatment responsiveness, providing new strategies and perspectives for PC therapy. This article reviews the formation of TLSs in PC, their anti-tumor effects, and applications in PC prognosis and treatment, providing a reference for in-depth research on TLSs in PC.

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