目的

分析术前免疫炎症指数（SII）、α-L-岩藻糖苷酶（AFU）水平对肝癌患者介入术后早期复发的预测价值。

方法

选取2021年7月至2023年7月接受肝癌介入术112例患者，依据是否复发分为复发组（n=34例）和未复发组（n=78例）。将数据导入SPSS 22.0进行分析，SII、AFU水平等符合正态分布的计量资料，以（±s）表示，行独立样本t检验；计数资料用［例（%）］表示，采用χ²检验；以Spearman秩相关分析术前SII、AFU水平与肝癌患者介入术后早期复发的相关性；以受试者特征工作曲线（ROC）评价术前SII、AFU水平对肝癌患者介入术后早期复发的预测价值。P＜0.05为差异有统计学意义。

结果

复发组患者术前SII、AFU水平高于未复发组（P＜0.05）；Spearman秩相关分析，术前SII、AFU水平与肝癌患者介入术后早期复发呈正相关（r=0.331、0.306，P＜0.05）；ROC曲线显示，术前SII、AFU水平联合预测肝癌患者介入术后早期复发的曲线下面积（AUC）为0.947，灵敏度为94.12%，特异性为92.31%，联合预测效能优于各指标单独预测（P＜0.05）。

结论

术前SII、AFU水平与肝癌患者介入术后早期复发密切相关，通过术前测定SII、AFU水平可为患者术后早期复发提供一定的预测价值。

Objective

To analyze the predictive value of the preoperative immune inflammatory index （SII） and the level of α-L-fucosidase （AFU） for the early recurrence.

Methods

A total of 112 patients who received interventional treatment for hepatocellular carcinoma from July 2021 to July 2023 were selected.According to whether recurrence occurred or not，they were divided into the recurrence group （n=34 cases） and the non-recurrence group （n=78 cases）.The data were imported into SPSS 22.0 for analysis.Measurement data conforming to the normal distribution，such as the levels of SII and AFU，were expressed as （±s），and the independent sample t test was performed.Count data were expressed as［ cases （%）］，and the χ² test was used.Spearman rank correlation analysis was carried out to analyze the correlation between the preoperative levels of SII and AFU and the early recurrence of patients with hepatocellular carcinoma after interventional treatment.The receiver operating characteristic curve （ROC） was used to evaluate the predictive value of the preoperative levels of SII and AFU for the early recurrence of patients with hepatocellular carcinoma after interventional treatment.A P value less than 0.05 was considered to indicate a statistically significant difference.

Results

The preoperative levels of SII and AFU in the recurrence group were higher than those in the non-recurrence group （P＜0.05）.Spearman rank correlation analysis showed that the preoperative levels of SII and AFU were positively correlated with the early recurrence of patients with hepatocellular carcinoma after interventional treatment （r=0.331，0.306，P＜0.05）.The ROC curve showed that the area under the curve （AUC） of the combined prediction of the early recurrence of patients with hepatocellular carcinoma after interventional treatment by the preoperative levels of SII and AFU was 0.947，the sensitivity was 94.12%，and the specificity was 92.31%.The combined predictive efficiency was better than that of each index alone （P＜0.05）.

Conclusion

The preoperative levels of SII and AFU are closely related to the early recurrence of patients with hepatocellular carcinoma after interventional treatment.Measuring the levels of SII and AFU before operation can provide certain predictive value for the early recurrence of patients after operation.