目的

分析乙型肝炎（HBV）肝硬化并发原发性肝癌的危险因素，以期为临床诊治提供参考。

方法

回顾性分析2018年7月至2023年7月76例HBV肝硬化并发原发性肝癌患者资料，设为研究组。另选择同期收治的84例HBV肝硬化患者作为对照组。采用SPSS 23.0统计软件对HBV肝硬化并发原发性肝癌的危险因素进行单因素分析与多因素 Logistic回归分析。

结果

单因素分析显示，研究组患者男性、年龄≥65岁、有肝癌家族史、有长期饮酒史、无抗病毒治疗、HBV-DNA定量＞2×10² IU/ml均高于对照组，差异有统计学意义（P＜0.05）。将差异因素纳入多因素 Logistic回归分析显示，男性、年龄≥65岁、有肝癌家族史、有长期饮酒史、无抗病毒治疗、HBV-DNA定量＞2×10² IU/ml是HBV肝硬化并发肝癌的独立危险因素（P＜0.05）。

结论

HBV肝硬化并发原发性肝癌的危险因素较多，临床上应对高危患者重点关注。

Objective

To analyze the risk factors for primary liver cancer complicating hepatitis B virus （HBV）-related liver cirrhosis，so as to provide a reference for clinical diagnosis and treatment.

Methods

The data of 76 patients with primary liver cancer complicating HBV-related liver cirrhosis from July 2018 to July 2023 were retrospectively analyzed and set as the study group.Another 84 patients with HBV-related liver cirrhosis admitted during the same period were selected as the control group.The statistical software SPSS 23.0 was used for univariate analysis and multivariate Logistic regression analysis of the risk factors for primary liver cancer.

Result

Univariate analysis showed that the proportions of male gender，age ≥ 65 years old，family history of liver cancer，long-term drinking history，no antiviral treatment，and HBV-DNA quantification ＞ 2×10² IU/ml in the study group were all higher than those in the control group，and the differences were statistically significant （P＜0.05）.Incorporating the above factors with differences into the multivariate Logistic regression analysis showed that male gender，age ≥ 65 years old，family history of liver cancer，long-term drinking history，no antiviral treatment，and HBV-DNA quantification ＞ 2×10² IU/ml were independent risk factors for liver cancer complicating HBV-related liver cirrhosis （P＜0.05）.

Conclusion

There are many risk factors for primary liver cancer complicating HBV-related liver cirrhosis，and high-risk patients should be given special attention in clinical practice.