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中华普外科手术学杂志(电子版) ›› 2023, Vol. 17 ›› Issue (02) : 226 -229. doi: 10.3877/cma.j.issn.1674-3946.2023.02.028

综述

吲哚菁绿用于外科术中神经显影的现状与展望
刘颂1, 胡琼源1, 陆晓峰1, 管文贤1,()   
  1. 1. 210008 南京,南京大学医学院附属鼓楼医院胃肠外科
  • 收稿日期:2022-12-19 出版日期:2023-04-26
  • 通信作者: 管文贤

Current situation and prospect of indocyanine green for surgical nerve imaging

Song Liu1, Qiongyuan Hu1, Xiaofeng Lu1, Wenxian Guan1,()   

  1. 1. Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing Jiangsu Province 210008, China
  • Received:2022-12-19 Published:2023-04-26
  • Corresponding author: Wenxian Guan
  • Supported by:
    National Natural Science Foundation of China(82172645); Key Research and Development Program of Jiangsu Province(Social Development)(BE2022667); Key Research and Development Program of Jiangsu Province(Frontiers in Clinical Technology)(BE2022753); Natural Science Foundation of Jiangsu Province for Outstanding Young Scholars(BK20200052)
引用本文:

刘颂, 胡琼源, 陆晓峰, 管文贤. 吲哚菁绿用于外科术中神经显影的现状与展望[J]. 中华普外科手术学杂志(电子版), 2023, 17(02): 226-229.

Song Liu, Qiongyuan Hu, Xiaofeng Lu, Wenxian Guan. Current situation and prospect of indocyanine green for surgical nerve imaging[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 226-229.

神经保护在外科手术中具有重要意义,与围手术期安全性及生理功能密切相关。以吲哚菁绿(ICG)为代表的近红外荧光示踪剂已广泛应用于临床。既往研究多围绕ICG的肿瘤成像与淋巴示踪功能,本文将回顾ICG在导航外科领域的应用历程,梳理ICG在术中神经显影与保护方面的临床证据,侧重于总结ICG神经显影的原理、给药方式及观察窗,展望ICG衍生类新型示踪剂、ICG近红外Ⅱ区(NIR-Ⅱ)成像等临床应用前景。

Neuroprotection plays an important role in surgery and is closely related to perioperative safety and physiological function. Indocyanine green(ICG)as the representative of near infrared fluorescence tracer has been widely used in clinic. Previous studies mainly focus on the tumor imaging and lymphatic tracer function of ICG. This paper reviews the application history of ICG in the field of navigation surgery,reviews the clinical evidence of ICG in intraoperative nerve development and protection,and focuses on summarizing the principle,administration mode and observation window of ICG nerve development. The prospects of clinical application of new tracers derived from ICG and ICG near infrared Ⅱ imaging are prospected.

表1 近年ICG临床应用指南或共识
年份 领域 指南或共识 制定者
2019[8] 肝脏外科 计算机辅助联合吲哚菁绿分子荧光影像技术在肝脏肿瘤诊断和手术导航中应用指南(2019版)

中华医学会

数字医学分会等

2019[9] 肝脏外科 吲哚菁绿荧光染色在腹腔镜肝切除术中应用的专家共识

中国研究型医院学会

微创外科学专业委员会等

2021[10] 肝胆外科 Consensus guidelines for the use of fluorescence imaging in hepatobiliary surgery Wang Xiaoying等
2020[11] 胃外科 吲哚菁绿近红外光成像在腹腔镜胃癌根治术中应用中国专家共识(2019版)

中华医学会外科学分会

胃肠外科学组等

2021[12] 结直肠外科 吲哚菁绿近红外光成像在腹腔镜结直肠癌手术中应用中国专家共识(2021版)

中华医学会外科学分会

结直肠外科学组等

2022[13] 口腔外科 吲哚菁绿荧光成像技术在口腔鳞癌治疗中的应用:中国专家共识 胡勤刚、张陈平等
2019[14] 泌尿外科 Best practices in near-infrared fluorescence imaging with indocyanine green (NIRF/ICG)-guided robotic urologic surgery: a systematic review-based expert consensus Giovanni Cacciamani等
2020[15] 妇科 Utility of intraoperative fluorescence imaging in gynecologic surgery: systematic review and consensus statement Mikel Gorostidi等
2022[16] 多学科 Consensus conference statement on the general use of near-infrared fluorescence imaging and indocyanine green guided surgery International Society for Fluorescence Guided Surgery (ISFGS)
表2 ICG用于术中体内神经显影的文献报道
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