胰腺癌为高致死率的消化道恶性肿瘤，早期即可发生区域淋巴结和远处转移，5年生存率不到6%，其首要转移途径为经淋巴结转移。淋巴结转移是导致胰腺癌患者极差预后的重要因素之一，如何有效的处理胰腺癌淋巴结转移已成为胰腺外科的热点与难点。目前标准淋巴结清扫已得到多数学者的认可，但是否行扩大淋巴结清扫以及清扫范围仍存较大争议。由于尚缺乏统一标准且各中心执行标准不一致，故目前尚无确切证据表明扩大淋巴结清扫的价值。我们团队总结回顾过去13年我中心行扩大淋巴结清扫的胰腺癌患者相关数据，我们认为扩大淋巴结清扫可清除可能残留的肿瘤组织和已有转移的阳性淋巴结，减少复发，延缓病情进展，延长患者总体生存时间。

Pancreatic ductal adenocarcinoma is one of the most malignant tumors with poor prognosis，which usually accompanies with regional lymph node and distant metastasis in early stage. The five-year survival rate is less than 6%，and the primary route of metastasis is lymph node metastasis. Lymph node metastasis is the key point of factors resulting in poor prognosis. How to figure out this problem，which has been the hotpot and difficulty in hepatopancreatobiliary surgery. At present，the standard lymph node dissection has been recognized. However，the clinical application of extended Lymphadenectomy remains controversial. Based on the 13 years clinical data from our department，we demonstrated that pancreaticoduodenectomy with extended lymphadenectomy contributes to remove residual tumor tissue and positive lymph nodes with metastasis，reduce recurrence，delay progression and improve the overall survival time.