分析胃癌患者术前中性粒细胞淋巴细胞比(NLR)、血小板淋巴细胞比(PLR)对淋巴结转移预测价值。

回顾性分析2016年1月至2018年6月行手术治疗的103例胃癌患者的临床病例资料，按病理结果分为淋巴结转移组(39例，转移组)与淋巴结无转移组(64例，对照组)；采用SPSS20.0软件进行数据分析，术前各炎症指标和NLR、PLR等定量资料采用(±s)表示，独立t检验；TNM分期等计数资料行χ²检验；绘制ROC曲线图，计算NLR、PLR的临界值。以P<0.05表示差异具有统计学意义。

术前两组白细胞计数差异无统计学意义(P＝0.156)；但术前淋巴结转移组患者中性粒细胞、血小板、淋巴细胞高于对照组，两组差异有统计学意义(P＝0.037, 0.044, 0.047)；术前淋巴结转移组患者NLR、PLR明显高于对照组(P均＝0.000)；NLR的曲线下面积为0.814, 95%CI为(0.688～0.851)，临界值为2.01，灵敏度88.4%、特异度43.1%；PLR的曲线下面积为0.809, 95%CI为(0.704～0.864)，临界值为148.63，灵敏度80.6%、特异度46.7%。

术前NLR、PLR对于胃癌患者淋巴结转移具有较高的预测价值，可作为术前淋巴结转移预测指标。

To analyze the value of preoperative neutrophil / lymphocyte ratio and platelet/lymphocyte ratio in predicting lymph nodes metastasis of patients with gastric cancer.

Clinical data of 103 patients with gastric cancer treated in our hospital from January 2016 to June 2018 were analyzed retrospectively. According to the pathological results, they were divided into lymph node metastasis group (39 cases) and no lymph node metastasis group (64 cases). Spss20.0 softwarewas used for data analysis.Measurement data such as preoperative inflammation index, NLRand PLR were presented as mean+ standard deviation and were examined by using t test. TNM staging and other count data were compared with χ² test. To draw the ROC curve and calculate the critical value of NLR, PLR. P<0.05 was considered assignificant difference.

There was no significant difference of white blood cell count betweentwo groups before operation (P=0.156). However, the neutrophils, platelets and lymphocytes in preoperative lymph node metastasis group were higher than those without lymph node metastasis group respectively with significant difference (P=0.037, 0.044, 0.047). The NLR and PLR ofpatients withlymph node metastasis was significantly higher than those of patients without lymph node metastasis, with significant difference (P=0.000). In terms of NLR, the area under the curvewas 0.814, the 95%CI was (0.688±0.851), the critical value was 2.01, the sensitivity was 88.4%, and the specificity was 43.1%. In terms of PLR The area under the curve of PLR was 0.809, 95% CI was (0.704~0.864), the critical value was 148.63, the sensitivity was 80.6%, and the specificity was 46.7%.

Preoperative NLR and PLR have potential value in predicting lymph node metastasis of patients with gastric cancer.