To compare the clinical effects of modified double purse-string pancreaticojejunostomy and greater omentum-wrapped pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy (LPD).

A prospective analysis was performed on the clinical data of 86 patients who underwent LPD from April 2020 to December 2023. According to the random number table method, the patients were divided into a control group (receiving modified double purse-string pancreaticojejunostomy) and an observation group (receiving greater omentum-wrapped pancreaticojejunostomy), with 43 patients in each group. Data were processed using SPSS 27.0 statistical software. Measurement data such as intraoperative blood loss and drainage time were expressed as (±s) and analyzed by independent sample t test; enumeration data such as the total incidence of postoperative complications and pathological types were expressed as [cases (%)] and analyzed by χ² test; ordinal data such as Clavien-Dindo classification were expressed as frequencies and analyzed by Rank Sum test. P<0.05 was considered statistically significant.

There were no significant differences between the two groups in intraoperative blood loss, drainage time, exhaust time, hospital stay, hospitalization cost, total incidence of postoperative complications, or Clavien-Dindo complication classification (P>0.05). The pancreaticojejunostomy time and operation time in the observation group were shorter than those in the control group (P<0.05). There was no significant difference in the 2-year overall survival rate between the two groups (P>0.05).

In laparoscopic pancreaticoduodenectomy, compared with the modified double purse-string pancreaticojejunostomy, the greater omentum-wrapped pancreaticojejunostomy has shorter pancreaticojejunostomy and operation times, and is equally safe and effective.