To analyze the clinical outcome of reoperation after parathyroidectomy for the recurrence of the secondary hyperparathyroidism in 16 patients.

The clinical data of 16 patients with recurrent secondary hyperparathyroidism after parathyroidectomy, who underwent reoperation from May 2017 to October 2019, were analyzed retrospectively. Statistical analysis were performed by using SPSS 22.0 software. Measurement data, such as Parathyroid volume, laboratory parameters, and quality of WHOQOL-BREF were expressed as (±s), and were examined by using paired sample t test. Surgical success rate, symptom improvement and postoperative complications were analyzed by using χ² test A P value <0.05 was considered as statistically significant difference.

15 of 16 patients (93.75%) received successful surgery. Compared with the preoperative period, patients' complains of skin pruritus, bone pain, fracture or bone deformity, muscle weakness with atrophy and ectopic calcification was much lower at 6 months after operation. Blood calcium (Ca) and phosphorus (P) levels are low, WHOQOL-BREF scores are high in all dimensions, with significant difference (P<0.05). There were no complications of hand and foot twitching, bleeding in the operation area, dyspnea and bone hunger syndrome in 16 patients. Hypocalcemia occurred in 5 cases, while short-term eating cough occurred in 1 case.

For the recurrence of secondary hyperparathyroidism after parathyroidectomy, the success rate of reoperation is pretty good with low complications, which could promote the improvement and disappearance of clinical symptoms, including reducing the serum iPTH level, avoiding the residual parathyroid glands, with improved life quality.