The prognosis of radical resection of right colon cancer has always been the focus of attention at home and abroad. At present, the concepts of Complete Mesocolic Excision (CME) and D3 lymph node dissection have been recognized generally that it could significantly reduce the postoperative local recurrence rate, improve survival rate and disease-free survival rate. However, there are still many controversies, including the options of surgical method and approach, the extent of radical colon resection and lymphadenectomy such as NO.6 lymph nodes. At the same time, with the rapid development of laparoscopy technology, the simple pursuit of minimally invasive concept has gradually turned into a more standardized radical resection concept. Based on long-term clinical practice, the authors recommended individualized surgical treatment strategies to ensure the safety and thoroughness of the operation as far as possible.