To investigate the effect of carbon nanoparticles tracer technique in radical resection of pancreatic cancer.

From June 2013 to December 2016, a retrospective analysis was performed in 52 patients with pancreatic cancer treated in our hospital, the patients were divided into carbon nanoparticle group and control group, 26 cases in each group, carbon nanoparticle lymphatic tracer was used in carbon nanoparticle group during operation. Statistical analysis was performed by SPSS 22.0 software, the perioperative indicators, number of lymph nodes and survival time were expressed as mean±standard deviation, and were examined by using t test. The positive lymph node ratio and post-operative complication rate were examined by using chi square test. The survival rate were examined by using Kaplan-Meier test. A P value of <0.05 was considered as significant difference.

There were no significant differences in the operation time, amount of post-operation drainage, intraoperative blood loss and average hospitalization time between the two groups (P>0.05). The average number of lymph nodes in carbon nanoparticle group (26.3±2.5) was significantly more than that (19.4±1.7) in the control group, and the number of lymph nodes whose diameter were less than 5 mm was significantly more than that in the control group[(8.1±1.7) vs. (5.3±1.0)], the average number of positive lymph nodes in carbon nanoparticle group (11.4±3.1) was significantly more than that (5.9±1.5) in control group; The mean required time for lymph nodes detection in carbon nanoparticle group (20.4±3.6) min was significantly shorter than that in control group (31.8±5.1) min. The positive lymph node ratio in carbon nanoparticle group (19.5%, 168/860) was significantly higher than that in control group (15.7%, 115/733). The rate of black-dyed lymph nodes in carbon nanoparticle group was (71.2%, 612/860). The positive lymph node ratio of black-dyed lymph nodes (24.1%, 148/612) was significantly higher than that of non-black-dyed lymph nodes(8.1%, 20/248) and the control group (P<0.05). The 1-, 2-, 3- years survival rate in carbon nanoparticle group were higher than those in control group (P<0.05). The mean survival time of carbon nanoparticle group(25.0±13.3 months) was significantly more than that of the control group (15.3±13.0 months) (P<0.05).

The application of carbon nanoparticles tracer technique in radical resection of pancreatic cancer can reach good effect, which increased the number of lymph node and positive lymph node dissection rate, improved the survival time and prognosis of patients.