Mesh infection is a postoperative complication following laparoscopic hernia repair, which is generally associated with mesh materials, surgical techniques and other factors. Such infections are often complicated by enteric fistulas and cutaneous fistulas, whereas concurrent bladder fistulas are extremely rare. This article reports the treatment course of one patient who developed mesh infection combined with enteric fistula and bladder fistula after laparoscopic hernia repair. The patient had a previous history of laparoscopic hernia repair, and presented with gross hematuria and dull hypogastric pain as chief complaints. After admission, comprehensive examinations including abdominal computed tomography (CT) and colonoscopy were completed. The patient underwent transurethral pneumatic lithotripsy for bladder calculi, transurethral electroresection of bladder lesions, and cecectomy to remove bladder stones and the infected mesh. By reporting this rare case, this paper discusses its potential pathogenesis, so as to avoid misdiagnosis and missed diagnosis of similar conditions.