To compare the clinical efficacy of laparoscopic precise hepatic pedicle dissection resection and conventional resection in the treatment of primary hepatocellular carcinoma (HCC).

The data of 113 patients with primary HCC who underwent laparoscopic liver cancer resection from May 2021 to May 2024 in our hospital were retrospectively analyzed. According to the different surgical methods, the patients were divided into the observation group (n=55, underwent laparoscopic precise hepatic pedicle dissection resection) and the control group (n=58, underwent laparoscopic conventional liver resection). Data were processed and analyzed using SPSS 27.0 software. Quantitative data were expressed as (

Compared with the control group, patients in the observation group had less intraoperative blood loss, less postoperative drainage volume, shorter postoperative extubation time, and shorter hospital stay (P<0.05). At 24 hours after surgery, the levels of serum C-reactive protein (CRP), interleukin-6 (IL-6), cortisol (Cor), and norepinephrine (NE) in both groups were higher than those before surgery; at 7 days after surgery, the levels of each indicator in both groups were lower than those at 24 hours after surgery, and the levels in the observation group at 24 hours and 7 days after surgery were lower than those in the control group (P<0.05). At 24 hours after surgery, the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) in both groups were higher than those before surgery; at 7 days after surgery, the levels of each indicator in both groups were lower than those at 24 hours after surgery, and the levels in the observation group at 24 hours and 7 days after surgery were lower than those in the control group (P<0.05). At 3 months after surgery, the levels of serum alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and soluble intercellular adhesion molecule-1 (sICAM-1) in both groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group (P<0.05). The incidence of postoperative complications in the observation group was 5.5%, which was lower than 19. 0% in the control group (P<0.05). At 1 year after surgery, the disease-free survival rate of patients in the observation group was 74. 6%, which was higher than 55.2% in the control group (P<0.05).

Compared with traditional laparoscopic conventional liver resection, laparoscopic precise hepatic pedicle dissection resection for primary HCC has the advantages of less intraoperative bleeding and less surgical trauma, which can reduce postoperative inflammatory stress and liver function damage, significantly inhibit the expression of tumor factors, and improve the postoperative disease- free survival rate.