R0 resection and lymphadenectomy are crucial components of radical surgery for pancreatic cancer. In patients with locally advanced pancreatic cancer who respond well to chemotherapy, dissection of the Heidelberg Triangle and total mesopancreatic excision can also improve the R0 resection rate. We categorize the peripancreatic lymph nodes around the pancreatic head into three regions: posterior, superior, and inferior. Through total mesopancreatic excision and a superior mesenteric artery-first approach, modular resection of the specimen along with all regional lymphatic and neural tissues can be achieved, contributing to a higher R0 resection rate.During mobilization of the pancreatic head and duodenum, lymph node stations 16b1 and 16a2 are dissected first. Subsequently, lymphadenectomy of the superior pancreatic region is performed, with the left gastric artery and vein as the left boundary, the common hepatic artery as the inferior boundary, and the portal vein along with the left hepatic artery as the right boundary. Lymph nodes in the superior region (stations 7, 8, 12a, 12p, 12b) can be removed en bloc together with those in the posterior region. Finally, dissection of the inferior region is carried out using the total mesopancreatic excision and superior mesenteric artery-first approach: the superior mesenteric artery is skeletonized, the inferior pancreaticoduodenal artery (IPDA) is ligated, and the inferior pancreaticoduodenal vein (IPDV) is divided. Lymph node stations 14a, 14b, 14c, and 14d can thus be excised en bloc.