Duodenal papillary adenoma is a rare benign tumor. If left untreated, the tumor may undergo malignant transformation and threaten the patient's life. Currently, available surgical approaches include pancreaticoduodenectomy, endoscopic resection, and transduodenal local resection of the tumor. Although conventional pancreaticoduodenectomy has evolved over time, it is still associated with high perioperative morbidity and mortality, representing a relatively high-risk procedure that is no longer the first-choice approach. Endoscopic resection is suitable for small tumors but has limitations for large or extensively invasive lesions and may lead to severe complications such as bleeding and perforation.In contrast, function-preserving laparoscopic resection of duodenal papillary tumors avoids extensive resection of adjacent organs and digestive tract reconstruction, resulting in lower surgical risk and better preservation of the patient's digestive function. Using a combined strategy of preoperative pancreatic duct/biliary stent placement followed by function-preserving laparoscopic resection of duodenal papillary tumors, we successfully resected a duodenal papillary adenoma that was not amenable to endoscopic resection. The patient recovered uneventfully postoperatively without severe complications. The brief surgical steps are as follows: (1) Preoperative placement of pancreatic duct and/or biliary stents; (2) Patient positioning in the supine split-leg position, 30° reverse Trendelenburg and left tilt, followed by trocar insertion; (3) Adequate mobilization of the descending duodenum via Kocher maneuver; (4) Longitudinal incision of the anterolateral duodenal wall to fully expose the duodenal papilla and tumor;(5) Incision along the tumor margin to expose the duodenal mucosa and submucosa; after identifying the muscularis mucosae, complete tumor resection is performed from the tumor base under the guidance of the pancreatic duct/biliary stent; (6) Nasointestinal tube placement after intraoperative frozen-section pathology confirms a benign tumor; (7) Repair and reconstruction of the duodenal papilla and suture closure of the medial duodenal wall; (8) Duodenal wall repair and seromuscular imbrication; (9) Drainage tube placement.