The surgical procedure and scope of lymph node dissection for colonic hepatic flexure cancer differ from those for ascending colon and ileal cancers because of the specificity of its location and biological behavior. Whether to clear lymph nodes in groups No.206 and No.204 and ligate vessels at the root remains controversial. We adopted a centralized and prioritized approach by first peeling away the dorsal lobe of the right hemicolonic mesentery from its attachment to the posterior peritoneum and then expanding Toldt’s space on the right side and crossing the fusion fascial space anterior to the pancreaticoduodenum. The surgical trunk was fully exposed, and the ileocolic, right colonic, accessory right colonic, and mesocolic vessels were sequentially ligated and transected, with careful attention paid to protecting Henle’s trunk to avoid hemorrhage during retraction. The lymph nodes in groups No.204 and No.206 were cleared medially from the lateral vascular arch of the greater curvature of the stomach on the cranial side, and the right vessels of the gastric omentum were ligated and transected at their roots. After severing the end of the left branch of the mesocolon vessel and the marginal vessel of the transverse colon, the transverse colon was transected with a linear stapler, the end of the ileum was transected with the same linear stapler approximately 15-20cm from the ileocecal side, and the specimen was removed en bloc. An intracorporeal overlap anastomosis between the ileum and the left part of the transverse colon with peristalsis was performed, and the common hole was closed with continuous 3-0 barbed sutures. the same 3-0 barbed sutures were used to close the mesenteric defect using continuous sutures. This procedure is suitable for resectable colorectal hepatic flexure cancer, and is safe and convenient surgical procedure is appropriate for future implementation.