Abstract:

Objective

To explore and compare the influence of radical resection of colon cancer and complete mesocolic excision （CME） on the expressions of serum miR-21 and miR-25-3p in patients with colon cancer （CC）.

Methods

Patients with stage I-III CC were included from June 2021 to June 2023.According to different surgical methods，they were divided into radical resection group （open radical resection of colon cancer） and CME group （laparoscopic CME）.The propensity matching score was used to exclude the influence of confounding factors of baseline data.Finally，75 patients with comparable baseline data were obtained in radical resection group and CME group.SPSS 27.0 software was used for data analysis.Enumeration data such as complications were expressed by［ cases （%）］ and χ² test was performed.Measurement data such as bowel resection length and expressions of miR-21 and miR-25-3p were expressed as （±s） by adopting independent sample t test.Kaplan-Meier method and Log-Rank test were used for survival analysis.P＜0.05 was statistically significant.

Results

The intraoperative blood loss in CME group was significantly less than that in radical resection group （P＜0.05），and the drainage tube removal time，exhaust time and hospitalization time were significantly shorter than those in radical resection group （P＜0.05），and the number of lymph node dissection was significantly more （P＜0.05），but there were no significant differences in the surgical time and bowel resection length between groups （P＞0.05）.The incidence rates of complications in CME group were significantly lower than those in radical resection group （P＜0.05）.At 1 week after surgery，the expression levels of miR-21 and miR-25-3p in the two groups were decreased significantly （P＜0.05），and the expression levels were significantly lower in CME group than those in radical resection group （P＜0.05）.Kaplan-Meier analysis showed that there were no statistical differences in cumulative overall survival rate （100.0% vs. 98.7%） and progression-free survival rate （97.3% vs. 90.7%） between groups （P＞0.05）.

Conclusion

Compared with radical resection of colon cancer，CME is more conducive to the recovery of patients with CC，and the latter one has fewer complications and can effectively reduce the risk of potential cancer metastasis and has better postoperative short-term prognosis.

Key words: Colonic Neoplasms, Complete Mesocolic Excision, microRNA