To explore the effect of different surgical timing on the long-term prognosis of patients with spontaneous rupture and hemorrhage of primary liver cancer.

A total of 110 patients with spontaneous rupture hemorrhage of primary liver cancer who were hospitalized from March 2015 to March 2020 were randomly selected as the study objects. Patients were divided into observation group（n=52 cases，operation time ≤2 weeks）and control group（n=58 cases，operation time > 2 weeks）according to the different time between spontaneous rupture bleeding and operation. SPSS 20.0 was used for statistical analysis. Perioperative indicators were expressed as（

There were no perioperative death cases between the two groups，and there was no significant difference in intraoperative blood loss，total hospital stay，incidence of greater omental implantation transfer and incidence of postoperative complications（P>0.05）. During the follow-up period，there was no significant difference in the number of patients with intrahepatic recurrence or extrahepatic metastasis between the two groups（χ²=0.036，0.459，P>0.05）. By the end of the 3-year follow-up，the overall survival rate（34.6% vs. 6.8%）and the tumor-free survival time（20 months vs. 6 months）in the observation group were significantly higher than those in the control group（P<0.05）.

Surgical treatment of patients with spontaneous rupture and hemorrhage of primary liver cancer within 2 weeks can help to prolong the tumor-free survival time，improve the overall survival rate，and have a good long-term prognosis，which is worthy of clinical attention.