To investigate the effect of different lymph node dissection in radical resection of intrahepatic cholangiocarcinoma（ICC）and its influence on the prognosis of patients.

Data of 85 ICC patients who received radical hepatectomy plus regional lymph node dissection（LND）from January 2018 to December 2021 were retrospectively selected，and divided into conventional group（n=33）and expanded group（n=52）according to the scope of intraoperative lymph node dissection. On the basis of routine dissection，left and right half liver enlarged lymph node dissection was performed according to the origin of the primary lesion）. SPSS 20.0 was used for data analysis. Measurement data were represented by（

Both groups of patients successfully completed the operation，no perioperative death cases. There were no significant differences in operation time，intraoperative bleeding，lymph node dissection，postoperative exhaust time，gastrointestinal function recovery time and postoperative hospitalization time in the extended group compared with the conventional group（P>0.05）. There was no significant difference in postoperative complication rate，recurrence rate and 1，3 and 5-year cumulative overall survival rate in the expanded group（P>0.05）.

For ICC patients who could be surgically resectable，no matter routine hepatoduodenal ligamenta and para-hepatic common artery lymph node dissection，or intraoperative combined with enlarged lymph nodes in the left half of hepatogastric flexus，near the gastric cardia，right half of hepatic portal vein，and head of pancreas according to the origin of the lesion，the prognosis of the patients was not affected. It is suggested that the scope of LND should be reasonably selected and personalized cleaning plan should be developed according to the underlying disease and actual status of lymph nodes in ICC radical resection，so as to avoid blindly expanding cleaning.