Comparative study of clinical value of three different tracer display schemes in breast cancer surgery

doi:10.3877/cma.j.issn.1674-3946.2022.05.014

Abstract

Abstract:

Objective

To investigate the clinical value of three different tracer display schemes in breast cancer surgery.

Methods

A total of 114 breast cancer patients from January 2018 to December 2020 were prospectively selected and divided into three groups by random number table method：MB group，ICG group and combined group，with 38 cases in each group. Methylene blue（MB）tracer method was used in MB group. Indocyanine green（ICG）tracer was used in ICG group. ICG+MB double tracer was used in the combined group. SPSS 22.0 software was used to process the data. The detection rate，accuracy rate and false negative rate of sentinel lymph node（SLN）were analyzed by χ² test. Measurement data such as tumor diameter were expressed as（

x ˉ

±s）. One-way ANOVA of variance was used for comparison between multiple groups，and LSD-t test was used for comparison between two groups. P<0.05 was considered statistically significant.

Results

The detection rates of SLN in MB group，ICG group and combined group were 78.9%，94.7% and 97.4%，respectively. The average number of SLN detected was（2.1±0.8），（2.5±0.9）and（2.8±1.1），respectively. The detection rate and average number of SLN detected in MB group were significantly lower than those in ICG group and combined group（P<0.05）. The detection accuracy of SLN in the combined group was 95.6%，which was significantly higher than that in the MB group（73.1%，χ²=6.333，P=0.042）. The false negative rate of SLN in combined group（4.1%）was significantly lower than that in MB group（17.6%），and the difference was statistically significant（χ²=6.417，P=0.040）.

Conclusion

ICG alone or in combination has achieved high diagnostic value，and ICG combined with MB dual tracer method has more advantages，not only improves the detection number，detection rate and accuracy of SLN，but also is more conducive to reducing the false negative rate of SLN.

Key words: Breast neoplasms, Sentinel lymph node biopsy, Methylene blue, Indocyanine green, Comparative effectiveness research

Chuanwei Sun, Shibu Lin, Manfei Jiang, Huangfu Wu, Luyao Wang, Rui Wang, Yan Yang. Comparative study of clinical value of three different tracer display schemes in breast cancer surgery[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(05): 518-521.

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Figures/Tables 4

References 16

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组别	例	年龄 (岁)	BMI (kg/m²)		肿瘤直径 (cm)		肿瘤位置
组别	例	年龄 (岁)	BMI (kg/m²)		肿瘤直径 (cm)		左/右
MB组	38	53.8±7.5	22.9±2.5		2.3±1.4		21/17
ICG组	38	55.1±6.8	23.3±2.3		2.2±1.6		19/19
联合组	38	54.6±7.7	22.6±2.6		2.4±1.3		20/18
F/χ²		0.303	0.768		0.184		0.211
P		0.739	0.466		0.833		0.900
组别	例	象限分布		病理类型		cTNM分期
组别	例	A/B/C		a/b/c		Ⅰ/Ⅱ
MB组	38	20/14/4		29/4/5		16/22
ICG组	38	21/12/5		30/3/5		17/21
联合组	38	22/12/4		28/4/6		15/23
F/χ²		0.460		0.376		0.216
P		0.977		0.984		0.898

组别	例	年龄 (岁)	BMI (kg/m²)		肿瘤直径 (cm)		肿瘤位置
组别	例	年龄 (岁)	BMI (kg/m²)		肿瘤直径 (cm)		左/右
MB组	38	53.8±7.5	22.9±2.5		2.3±1.4		21/17
ICG组	38	55.1±6.8	23.3±2.3		2.2±1.6		19/19
联合组	38	54.6±7.7	22.6±2.6		2.4±1.3		20/18
F/χ²		0.303	0.768		0.184		0.211
P		0.739	0.466		0.833		0.900
组别	例	象限分布		病理类型		cTNM分期
组别	例	A/B/C		a/b/c		Ⅰ/Ⅱ
MB组	38	20/14/4		29/4/5		16/22
ICG组	38	21/12/5		30/3/5		17/21
联合组	38	22/12/4		28/4/6		15/23
F/χ²		0.460		0.376		0.216
P		0.977		0.984		0.898

组别	例	检出例数	检出数 (枚)	检出率 (%)	平均检出数 (枚)
MB组	38	30	78	78.9	2.1±0.8
ICG组	38	36	96	94.7^a	2.5±0.9^a
联合组	38	37	113	97.4^a	2.8±1.1^a
F/χ²		-	-	7.265	4.933
P		-	-	0.026	0.009

组别	例	检出例数	检出数 (枚)	检出率 (%)	平均检出数 (枚)
MB组	38	30	78	78.9	2.1±0.8
ICG组	38	36	96	94.7^a	2.5±0.9^a
联合组	38	37	113	97.4^a	2.8±1.1^a
F/χ²		-	-	7.265	4.933
P		-	-	0.026	0.009

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