To investigate the influencing factors of severe complications after laparoscopic pancreaticoduodenectomy.

The clinical data of 120 patients who underwent laparoscopic pancreaticoduodenectomy (LPD) from June 2017 to June 2020 were analyzed retrospectively. The incidence of postoperative complications was observed, with classifing the severity by using Clavien. Dindo methods. Statistical analysis were performed by using SPSS 22.0 software. The single factor and multiple factors analysis were performed by using Logistic regression analysis and were examined by using Chi-square test. The relationship between 15 clinical factors was analyzed, such as the occurrence of serious complications. A P value of <0.05 was considered as statistically significant difference.

Among the 120 patients, 34 (28.3%) cases had complications after LPD, while 14 (11.7%) cases with severe complications. Univariate analysis showed that the age of >60 years old, preoperative serum ALB of <less than 35.7 g/L, anastomotic mode, intraoperative blood loss of >300 ml, intraoperative blood transfusion of >800 ml and the soft pancreas were the influential factors of serious complications after LPD (P<0.05). Multivariate results showed that the age of > 60 years old, intraoperative blood transfusion of >800 ml, intussusception anastomosis and soft pancreatic texture were the independent factors affecting the occurrence of serious complications after LPD (P<0.05).

The age of >60 years old, intraoperative blood transfusion of >800 ml, intussusception anastomosis and soft pancreatic texture might be the influential factors of severe complications after LPD.