To analyze the effect of enhanced recovery after surgery (ERAS) on postoperative rehabilitation and stress factors of patients with cholecystolithiasis complicated with choledocholithiasis.

Seventy-one patients with cholecystolithiasis complicated with choledocholithiasis were divided into ERAS group (n=35) and routine group (n=36). The routine group received routine perioperative rehabilitation intervention, while ERAS group received perioperative intervention based on ERAS concept. Both groups received laparoscopic cholecystectomy+ choledocholithotomy+ choledochoscope exploration+ primary suture of common bile duct or T\\tube drainage, and all the operations were performed by doctors in the same group. SPSS 22.0 software was used to analyze the data. The indexes of intraoperative and postoperative liver function and inflammatory factors were expressed as (±s), and independent t test was performed. The incidence of complications was tested by χ² tests. The difference was statistically significant (P<0.05).

The postoperative exhaust time, postoperative defecation time, postoperative rehydration amount, postoperative hospitalization time, hospitalization expenses and postoperative complication rate in ERAS group were lower than those in routine group (P<0.05). AST, ALT and TBIL decreased 3 days after operation, On the 3rd day after operation, IL-6 and TNF-α increased and IL-10 decreased in both groups, especially in the routine group (P<0.05). The PRA, Ang-2, ALD in the two groups increased 3 days after operation, especially in the routine group (P<0.05).

Perioperative management based on ERAS concept can promote early rehabilitation of patients with cholecystolithiasis complicated with choledocholithiasis after laparoscopic surgery, reduce inflammatory reaction and stress reaction, and improve surgical safety.