Abstract:
Objective To investigate the short-term clinical outcome and survival analysis of laparoscopic radical cholecystectomy for primary gallbladder cancer.
Methods Retrospective analysis were performed in 83 cases with primary gallbladder cancer from October 2015 to October 2016. According to different surgical methods, the patients were divided into simple group (39 cases) and radical group (44 cases). Patients in the simple group underwent laparoscopic cholecystectomy alone, and patients in the radical group underwent laparoscopic radical cholecystectomy. Statistical analysis were performed by using SPSS 23.0 software. Measurement data, such as operation-related indexes and median survival time were expressed as . Independent sample t test was used for comparison between the two groups, and paired t test was used for comparison within the group. Complications, recurrence rate and survival rate were expressed as rates. Chi square test was used for comparison between the two groups, Kaplan-Meier method was used to compare the progression-free survival of the two groups. P<0.05 was considered as statistically significant difference.
Results The operation time in the radical group were more than those in simple group (P<0.05). There was no significant difference in terms of blood loss, first bed time, anal exhaust time, and length of hospital stay between the two groups (P>0.05). The 1-year and 3-year survival rates (77.3% and 47.7%) in the radical group were higher than those in the simple group (56.4% and 25.6%) respectively (P<0.05). The one-year recurrence rate of 2.3% in the radical group was lower than 17.9% in the simple group(P<0.05). There was no significant difference between the two groups in terms of the total incidence of postoperative complications (P>0.05). The median survival time of patients in the simple group within 3 years after operation was (21.0±1.8) months, which was lower than (25.9±1.6) months of patients in the radical group, with statistically significant difference (t=13.1309, P=0.0000).
Conclusion Laparoscopic radical cholecystectomy in the treatment of primary gallbladder cancer could effectively improve the short-term clinical outcome of patients with stage Ⅱ primary gallbladder cancer, reduce the recurrence rate after surgery, and improve the survival with higher safety.
Key words:
Gallbladder neoplasms,
Cholecystectomy, laparoscopic,
Treatment outcome,
Survival analysis,
Laparoscopic radical surgery
Tao Chu, Xiao Dong, Rongjin Shao, Shengdong Chen, Xu Lvy, Weida Gong. Short-term clinical outcome and survival analysis of laparoscopic radical cholecystectomy for primary gallbladder cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(03): 343-346.