Comparative study of carbon nanoparticles and indocyanine green-guided lymphadenectomy during laparoscopic radical gastrectomy

doi:10.3877/cma.j.issn.1674-3946.2021.02.009

Abstract

Abstract:

Objective

To compare the advantages between carbon nanoparticles (CN) and indocyanine green (ICG)-guided lymphadenectomy in laparoscopic radical gastrectomy.

Methods

Between January 2016 and December 2019, clinical data of 167 patients underwent laparoscopic radical gastrectomy were analyzed retrospectively. Among them, 130 patients received CN-guided gastrectomy and the other 37 patients received ICG-guided gastrectomy. GraphPad Prism 8.0 was employed for data analysis. Measurement data were presented as, and analyzed by using unpaired t-test. Count data were presented as frequency, and were compared by using χ² test. A P value of <0.05 was considered as statistical significant difference.

Results

The total number of harvested lymph nodes were similar in patients with same pathological stage. Lymph node examination could improve the number of retrieved lymph nodes. CN is superior to ICG in the harvest of No.5 lymph nodes in laparoscopic total gastrectomy, No.1 lymph nodes in laparoscopic proximal gastrectomy and total number in laparoscopic distal gastrectomy. Statistical difference in the positive rate of lymph node was not observed between two groups.

Conclusions

The effect of CN and ICG in guiding lymph node dissection was similar in patients with same pathological stage. Lymph node examination should be encouraged in laparoscopic radical gastrectomy. CN was superior than ICG in the harvest of No.5 in laparoscopic total gastrectomy, in the harvest of No.1 in laparoscopic proximal gastrectomy and total number of lymph nodes in laparoscopic distal gastrectomy.

Key words: Stomach neoplasms, Laparoscopy, Nanotubes, carbon, Indocyanine green, Lymph nodes

Xiaofeng Lu, Song Liu, Shichao Ai, Xuefeng Xia, Xiaofei Shen, Peng Song, Xing Kang, Liming Zheng, Meng Wang, Wenxian Guan. Comparative study of carbon nanoparticles and indocyanine green-guided lymphadenectomy during laparoscopic radical gastrectomy[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(02): 146-149.

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Figures/Tables 7

References 22

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组别	例数	年龄(岁)	性别	病理分期
组别	例数	年龄(岁)	男/女	Ⅰ/Ⅱ/Ⅲ
纳米碳组	130	58.5±11.2	78/52	77/26/27
ICG组	37	59.1±12.9	27/10	29/3/5
t/χ²		0.25	1.13	4.80
P值		0.81	0.18	0.09

组别	例数	年龄(岁)	性别	病理分期
组别	例数	年龄(岁)	男/女	Ⅰ/Ⅱ/Ⅲ
纳米碳组	130	58.5±11.2	78/52	77/26/27
ICG组	37	59.1±12.9	27/10	29/3/5
t/χ²		0.25	1.13	4.80
P值		0.81	0.18	0.09

组别	例数	手术时长(min)	术中出血量(ml)	术后住院天数(d)
纳米碳组	130	250.5±55.2	142.7±107.1	11.8±3.9
ICG组	37	260.8±43.4	145.9±72.1	13.0±8.7
t/χ²		1.04	0.17	1.24
P值		0.30	0.86	0.21
组别	例数	术后并发症(例)	二次手术(例)
纳米碳组	130	13	2
ICG组	37	2	1
t/χ²		0.89	1.17
P值		0.53	0.53

组别	例数	手术时长(min)	术中出血量(ml)	术后住院天数(d)
纳米碳组	130	250.5±55.2	142.7±107.1	11.8±3.9
ICG组	37	260.8±43.4	145.9±72.1	13.0±8.7
t/χ²		1.04	0.17	1.24
P值		0.30	0.86	0.21
组别	例数	术后并发症(例)	二次手术(例)
纳米碳组	130	13	2
ICG组	37	2	1
t/χ²		0.89	1.17
P值		0.53	0.53

组别	例数	Ⅰ期	Ⅱ期	Ⅲ期
纳米碳组	130	27.0±11.7	31.9±10.4	31.6±10.0
ICG组	37	23.8±8.3	32.3±17.4	29.8±13.3
t值		1.34	0.07	0.36
P值		0.19	0.94	0.72

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