To explore the factors influencing the prognosis of modified radical mastectomy (NSM) for breast cancer with preserved papillary areola complex.

A retrospective analysis was performed on the clinicopathological data of 84 patients with early primary breast cancer who underwent NAC retention modified radical mastectomy from January 2011 to December 2014. Postoperative recurrence and metastasis were observed, data entry was analyzed using statistical software SPSS 20.0, and postoperative disease-free survival (DFS) and overall survival (OS) were evaluated using K-M survival curve.K-M univariate analysis and Cox multivariate analysis were used to explore the influencing factors on DFS and OPS of patients after NSM surgery.

Postoperative local recurrence was found in 8 cases and distant metastasis in 6 cases. The 5-year survival curve of K-M was 83.3% for DFS and 91.7% for OS. Multivariate analysis showed that maximum tumor diameter, tumor distance from the nipple and areola (TND), axillary lymph node status, histological type and positive Her-2 were independent risk factors affecting DFS (P<0.05); Axillary lymph node status was an independent risk factor for postoperative OS (P<0.05).

Maximum tumor diameter, TND, axillary lymph node status, histological type and positive Her-2 were independent risk factors for DFS, while axillary lymph node status was an independent risk factor for OS. The status of axillary lymph nodes affects both postoperative DFS and OS, and preoperative systematic, accurate evaluation and proper treatment of special axillary lymph nodes can improve the prognosis of breast cancer patients.