To investigate the impact of surgical timing on the two-year clinical outcome of patients with both severe acute biliary pancreatitis and gallstones.

A retrospective analysis were performed in 87 cases of gallbladder stones with severe acute biliary pancreatitis from January 2016 to March 2018. According to the surgical timing, 42 patients underwent surgery within 3 days after admission were divided into the early surgery group, while 45 patients underwent surgery 1 month after the remission of pancreatitis were divided into the delayed surgery group. SPSS 24.0 software was used for data processing. Measurement data such as perioperative indexes and scores of APAHCE-Ⅱ were expressed as (±s), and t test was used. Count data such as total complication rate was expressed as a percentage, and χ² test was used. Kaplan-Meier method was used for postoperative survival analysis and Log-Rank was used for testing. A P value of <0.05 was considered as statistically significant.

In the delayed surgery group, the operation time, intraoperative blood loss, postoperative hospital stay, and conversion rate of laparotomy were much lower than those in the early surgery group respectively (P<0.05). The scores of postoperative APAHCE-Ⅱ, recurrence rate, and total complication rate in the early surgery group were much lower than those in the delayed surgery group respectively (P<0.05). There was no significant difference in terms of two-year survival rate between the two groups (P>0.05).

For patients with both cholecystolithiasis and severe acute gallstone pancreatitis, laparoscopic surgery within 3 days of admission could reduce the risk of recurrence and complications, and has no significant adverse effect on the prognosis.