Predictive value of systemic immune inflammation index in patients with acute pancreatitis complicated with organ function impairment

doi:10.3877/cma.j.issn.1674-3946.2025.01.019.

Abstract

Abstract:

Objective

To investigate the predictive value of systemic immunoinflammatory index （SII）in patients with acute pancreatitis complicated with organ function injury.

Methods

The data of 168 patients with acute pancreatitis from January 2020 to June 2023 were retrospectively analyzed.According to whether the patients had organ function injury， the patients were divided into injury group （n=48 cases） and control group（n=120 cases）.SPSS26.0 statistical software was used to analyze the data， SII and other measurement data were expressed as （x ± s）， and independent sample t test was performed.Receiver operating characteristic curve（ROC） was used to analyze the predictive value of SII in organ function injury in patients with acute pancreatitis.Multi-factor Logistics regression analysis was used to investigate the independent risk factors of organ function injury in patients with acute pancreatitis.When P＜0.05， the difference was considered statistically significant（bilateral）.

Results

Compared with the control group， SII was significantly increased in the injured group［（1012.2±281.2） vs. （662.0±167.9）， P=0.000］.Multi-factor Logistics regression analysis showed that SII＞818.0， APPACHE Ⅱ score ＞8.5 and pancreatic necrosis infection were independent risk factors for organ function impairment in patients with acute pancreatitis （P＜0.05）.SII was significantly positively correlated with Ranson score， APPACHEⅡ score， C-reactive protein and IL-6 in patients with acute pancreatitis （P＜0.05）.SII， Ranson score and APPACHEⅡ score all have certain predictive value for organ function injury in patients with acute pancreatitis， among which SII has a higher predictive value， and the area under the curve is 0.902（95% confidence interval: 0.846-0.958， P=0.000）.Compared with the control group， the mechanical ventilation rate， continuous hemofiltration rate， surgical drainage rate and in-hospital mortality were significantly increased in the injured group， and the length of hospitalization was extended （P＜0.05）.

Conclusion

The increase of SII is an independent factor of organ function impairment in patients with acute pancreatitis， and can be used as a new predictor of organ function impairment in patients with acute pancreatitis.

Key words: Acute Pancreatitis, Systemic Immune Inflammation Index, Organ Dysfunction

Jie Zhang, Xiaoxia Luo, Hong Yu. Predictive value of systemic immune inflammation index in patients with acute pancreatitis complicated with organ function impairment[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(01): 68-71.

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Figures/Tables 6

类别	损伤组（n=48）	对照组（n=120）	t/χ²值	P值
年龄（岁， $\overset{ˉ}{x}$ ±s）	48.4±5.3	49.0±5.8	0.679	0.498
性别［例（%）］			0.000	1.000
男性	28（58.3）	70（58.3）
女性	20（41.7）	50（41.7）
体重指数（kg/m²， $\overset{ˉ}{x}$ ±s）	24.4±3.8	25.0±3.9	0.936	0.351
病因［例（%）］			1.323	0.516
胆源性	32（66.7）	80（61.5）
高甘油三酯	8（16.7）	18（13.9）
酒精性	8（16.7）	32（24.6）
中性粒细胞（%， $\overset{ˉ}{x}$ ±s）	0.8±0.1	0.79±0.05	2.748	0.007
淋巴细胞（%， $\overset{ˉ}{x}$ ±s）	0.1±0.0	0.20±0.1	7.442	0.000
血小板（10⁹/L， $\overset{ˉ}{x}$ ±s）	146.7±23.7	115.4±28.6	6.714	0.000
SII（ $\overset{ˉ}{x}$ ±s）	1012.2±281.2	662.0±167.9	9.935	0.000
C反应蛋白（mg/L， $\overset{ˉ}{x}$ ±s）	18.0±4.2	12.7±3.9	7.845	0.000
IL-6（pg/ml， $\overset{ˉ}{x}$ ±s）	39.2±9.8	28.3±7.5	7.778	0.000
Ranson评分（ $\overset{ˉ}{x}$ ±s）	3.0±1.8	2.18±1.2	3.383	0.001
APPACHE Ⅱ评分（ $\overset{ˉ}{x}$ ±s）	10.1±2.7	7.8±2.6	5.087	0.000
胰腺坏死感染［例（%）］	18（37.5）	12（10.0）	17.677	0.000

类别	损伤组（n=48）	对照组（n=120）	t/χ²值	P值
年龄（岁， $\overset{ˉ}{x}$ ±s）	48.4±5.3	49.0±5.8	0.679	0.498
性别［例（%）］			0.000	1.000
男性	28（58.3）	70（58.3）
女性	20（41.7）	50（41.7）
体重指数（kg/m²， $\overset{ˉ}{x}$ ±s）	24.4±3.8	25.0±3.9	0.936	0.351
病因［例（%）］			1.323	0.516
胆源性	32（66.7）	80（61.5）
高甘油三酯	8（16.7）	18（13.9）
酒精性	8（16.7）	32（24.6）
中性粒细胞（%， $\overset{ˉ}{x}$ ±s）	0.8±0.1	0.79±0.05	2.748	0.007
淋巴细胞（%， $\overset{ˉ}{x}$ ±s）	0.1±0.0	0.20±0.1	7.442	0.000
血小板（10⁹/L， $\overset{ˉ}{x}$ ±s）	146.7±23.7	115.4±28.6	6.714	0.000
SII（ $\overset{ˉ}{x}$ ±s）	1012.2±281.2	662.0±167.9	9.935	0.000
C反应蛋白（mg/L， $\overset{ˉ}{x}$ ±s）	18.0±4.2	12.7±3.9	7.845	0.000
IL-6（pg/ml， $\overset{ˉ}{x}$ ±s）	39.2±9.8	28.3±7.5	7.778	0.000
Ranson评分（ $\overset{ˉ}{x}$ ±s）	3.0±1.8	2.18±1.2	3.383	0.001
APPACHE Ⅱ评分（ $\overset{ˉ}{x}$ ±s）	10.1±2.7	7.8±2.6	5.087	0.000
胰腺坏死感染［例（%）］	18（37.5）	12（10.0）	17.677	0.000

变量	B值	标准误	Wald值	P值	相对危险度（95%可信区间）
SII＞818	2.494	0.031	8.392	0.001	2.117（1.441-5.736）
Ranson评分＞2.5	1.049	0.035	3.023	0.082	0.936（0.882-1.632）
APPACHE Ⅱ评分＞8.5	1.563	0.391	4.490	0.004	1.420（1.084-2.994）
胰腺坏死感染	2.763	0.308	9.045	0.000	2.872（1.872-5.332）
C反应蛋白＞14.5mg/L	1.879	0.274	7.423	0.001	1.743（1.244-2.984）
IL-6＞34.5pg/ml	1.983	0.289	7.663	0.000	1.894（1.352-3.122）
常系数	4.513	1.294	14.778	0.000	-

变量	Ranson评分	APPACHE Ⅱ评分	C反应蛋白	IL-6
r值	0.363	0.241	0.344	0.300
P值	0.000	0.002	0.000	0.000

变量	曲线下面积	标准误	P值	95%可信区间	最佳诊断界值	敏感性	特异性
SII	0.902	0.029	0.000	0.846-0.958	818.0	0.833	0.950
Ranson评分	0.623	0.052	0.013	0.521-0.724	2.5	0.583	0.650
APPACHE Ⅱ评分	0.714	0.044	0.000	0.628-0.801	8.5	0.708	0.592
C反应蛋白（mg/L）	0.799	0.036	0.000	0.728-0.871	14.5	0.750	0.617
IL-6（pg/ml）	0.798	0.041	0.000	0.717-0.879	34.5	0.667	0.775

类别	损伤组（n=48）	对照组（n=120）	t/χ²值
机械通气［例（%）］	14（29.2）	0（0.0）	38.182
持续性血液滤过治疗［例（%）］	18（37.5）	6（5.0）	29.575
外科引流［例（%）］	18（37.5）	12（10.0）	17.677
院内死亡率［例（%）］	7（14.6）	1（0.8）	14.293
住院时间（d， $\overset{ˉ}{x}$ ±s）	28.6±6.4	18.5±7.1	8.553

类别	损伤组（n=48）	对照组（n=120）	t/χ²值
机械通气［例（%）］	14（29.2）	0（0.0）	38.182
持续性血液滤过治疗［例（%）］	18（37.5）	6（5.0）	29.575
外科引流［例（%）］	18（37.5）	12（10.0）	17.677
院内死亡率［例（%）］	7（14.6）	1（0.8）	14.293
住院时间（d， $\overset{ˉ}{x}$ ±s）	28.6±6.4	18.5±7.1	8.553

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