To compare the changes of oxidation, stress, T cells and inflammatory factors before and after laparoscopic and open gastric cancer D2 radical surgery for patients with advanced gastric cancer.

From January 2016 to December 2018, 80 patients undergoing D2 radical resection of gastric cancer were selected as the research objects. According to different surgical procedures, they were divided into laparoscopic group and laparotomy group, each with 40 cases. SPSS19.0 statistical software was used to analyze, operation-related indexes, 24 h oxidative stress and oxidative stress indexes before and after operation, T cell function indexes, and inflammatory factor indexes were expressed as (±s), and independent t test was adopted; Count data such as complications were tested by χ² test, and P<0.05 was considered statistically significant.

The operation time of the patients in the laparoscopic group was longer than that of the open group, and the other operation-related indexes were less than those in the open group (P<0.05). The level of superoxide dismutase (SOD) in the laparoscopic group was higher than that in the open group, and the levels of malondialdehyde (MDA) and 8-hydroxydeoxyuridine (8-OHdG) were lower than those in the open group (P<0.05); The levels of CD4⁺ , CD3⁺ , CD4⁺ /CD8⁺ in the laparoscopic group were higher than those in the open group (P<0.05).

Compared with laparotomy, laparoscopic gastric cancer D2 radical surgery for patients with advanced gastric cancer has less damage to the patient, and the patient's postoperative immune function, oxidative stress function and inflammatory factor. levels fluctuate less, which is more conducive to the patient's postoperative restore.