To analyze the effect of different methods of cholecystectomy combined with common bile duct exploration on coagulation function and stress response in patients with cholecystolithiasis and choledocholithiasis.

The 150 patientstreated in our hospital from July 2016 to February 2019 were enrolled in this part. They were randomly divided into two groups, control group (n=70) and observation group (n=80). Patients in the control group were treated with routine open surgery, while patients in the observation group were treated with laparoscopic cholecystectomy combined with common bile duct exploration. The changes of coagulation function and stress response in the two groups were analyzed. SPSS21.0 statistical software was used to analyze. Independent t-test was used for comparison between groups. The incidence of postoperative complications was compared by Chi-square test. P<0.05 signified statistical significance.

Compared with the control group, the bleeding volume, operation time, anal exhaust time and recovery time of gastrointestinal function in observation group were significantly shorter (P<0.05). After treatment, the levels of CRP, PCT, IL and IL6 in both groups were significantly increased (P<0.05). The above-mentioned indexes in the control group were increased more significantly (P<0.05). Compared with the control group, the incidence of complications in the observation group was significantly lower (P<0.05). There was no significant difference in coagulation function between the two groups before and after treatment (P>0.05).

Laparoscopic cholecystectomy combined with common bile duct exploration can effectively treat gallbladder with common bile duct stones without causing drastic changes in stress response.