To investigate the intestinal mucosal permeability of patients after laparoscopic radical total gastrectomy by using Un-cut or traditional Roux-en-Y anastomosis.

Retrospective analysis were performed in 60 patients with gastric cancer from January 2017 to February 2019, who underwent laparoscopic radical total gastrectomy. According to the method of digestive tract reconstruction, 30 patients with Un-cut Roux-en-Y anastomosis were divided into group A, while 30 patients with traditional Roux-en-Y anastomosis were divided into group B. Statistical analysis were perfomed by using SPSS23.0 software. Measurement data such as perioperative indicators, intestinal mucosal permeability indicators were represented as (±s) and were examined by using independent t test. Postoperative complications were analyzed by using χ² test. A P value of <0.05 was considered as statistical significant difference.

The intraoperative blood loss in group A was less than that in group B, and the postoperative recovery and exhaust time were shorter than those in group B, with significant difference (P<0.05). The incidence of RSS in group B was higher than that in group A, with significant difference (P<0.05). The L/M value, plasma d-lactic acid level, serum endotoxin level and DAO value in group A were lower than those in group B, and the plasma Gln level was higher than those in group B, with significant difference (P<0.05). There was no significant difference between the two groups in terms of perioperative indicators and incidence of complications (P>0.05).

Compared with traditional Roux-en-Y anastomosis, Un-cut Roux-en-Y anastomosis has the clinical advantages of less blood loss, faster recovery of exhaust time, lower incidence of Roux stasis syndrome, and less influence on intestinal permeability of patients, which could be popularized and applied.