To investigate the clinical effect of laparoscopic-assisted total gastrectomy (LATG) combined with D2 lymph node dissection in the treatment of advanced gastric cancer.

70 patients with advanced gastric cancer who underwent surgery in our hospital from May 2015 to May 2018 were analyzed retrospectively. They were divided into the laparoscopic group (39 cases who received LATG combined with D2 lymph node dissection) and the laparotomy group (31 cases who received laparotomy). SPSS21.0 software was used for statistical analysis. Intraoperative and postoperative indicators and serological related indicators before and after surgery were expressed by (±s), and examined by t test. Postoperative complications were analyzed by χ² test. P<0.05 had significant difference.

The operation time of the laparoscopic group was longer than that of the laparotomy group (P<0.05). The bleeding volume, incision length, first exhaust time and hospitalization time of the laparoscopic group were lower than those of the laparotomy group (P<0.05). There was no significant difference in lymph node dissection between the two groups (P>0.05). Before operation, there was no significant difference in WBC, N, Cor and CRP levels between the two groups (P>0.05); on the 1st, 4th and 7th day after operation, the indexes were significantly higher than those before operation (P<0.05); on the 1st day after operation, the levels of Cor and CRP in the laparoscopic group were lower than those in the laparotomy group, and on the 4th day after operation, the CRP in the laparoscopic group was lower than that in the laparotomy group (P<0.05). There was no significant difference of the incidence of postoperative complications between the two groups (P>0.05).

LATG combined with D2 lymph node dissection for advanced gastric cancer has the advantages of less trauma and less stress reaction.