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Chinese Journal of Operative Procedures of General Surgery(Electronic Edition) ›› 2019, Vol. 13 ›› Issue (05): 501-503. doi: 10.3877/cma.j.issn.1674-3946.2019.05.023

Special Issue:

• Original Article • Previous Articles     Next Articles

Retrospective analysis of interventional therapy for 66 cases of hilar cholangiocarcinoma with obstructive jaundice

Ming Cheng1,()   

  1. 1. Shengjing Hospital Affiliated to China Medical University General Surgery 110031
  • Received:2019-02-05 Online:2019-10-26 Published:2019-10-26
  • Contact: Ming Cheng
  • About author:
    Corresponding author: Chen Ming, Email:

Abstract:

Objective

To study the effect of interventional therapy in patients with hilar cholangiocarcinoma complicated with obstructive jaundice and to explore the factors influencing the clinical prognosis.

Methods

The data of 66 cases of hilar cholangiocarcinoma complicated with obstructive jaundice from January 2014 to June 2017 were retrospectively analyzed to observe the clinical prognosis of interventional therapy. Data were analyzed using spss19.0 statistical software. Liver function index was showed as ±s, compared with t test; Univariate and multivariate analyses were performed by non-conditional Logistic regression. P<0.05 was statistically significant.

Results

The survival rate at 12 months after interventional therapy was 80.3%, and of which the symptoms of obstructive jaundice disappeared. Liver function indexes (TBIL, ALT, IBIL, GOT) were significantly lower after treatment (all P<0.05). Tumor stage (OR=3.034, P=0.014), degree of obstruction (OR=1.143, P=0.014), child-pugh grade of liver function (OR=3.493, P=0.014), frequency of interventional therapy (OR=1.562, P=0.014) and subsequent chemotherapy (OR=3.146, P=0.014) were independent risk factors for survival of interventional therapy (all P<0.05).

Conclusion

Interventional therapy can significantly improve the liver function of patients with hilar cholangiocarcinoma complicated with obstructive jaundice, and reduce the symptoms of obstructive jaundice.

Key words: Bile duct neoplasms, Jaundice, obstructive, Radiology, interventional, Treatment outcome

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