To investigate the local recurrence of three negative breast cancer after breast conserving surgery, modified radical mastectomy and breast conserving therapy combined with radiotherapy.

320 cases of three negative breast cancer patients from January 2009 to December 2014 treated in our hospital were selected as the research object, according to the operation, they were divided into breast conserving surgery group(BCT), 132 cases, modified radical surgery group (MRM), 120 cases, breast conserving therapy combined with radiotherapy (BCT & RT) group, 68 cases. The general information of patients, surgery, hospitalization time between three groups were compared with one-way ANOVA and Pearson χ² test, and the postoperative 3 years local recurrence risk was analyzed with Cox regression.

No significant difference in operation time of BCT group, MRM group, MRM and RT group was found (P>0.05), blood loss and hospitalization time, incision length of BCT were significantly better than those of MRM, (P<0.05); 3 years after surgery, the risk of local recurrence in BCT group and MRM group were 2.37 times, 2.24 times than in the BCT and RT group (P<0.05), chest wall metastasis risk is 3.14 times, 3.85 times than in the BCT and RT group (P<0.05); the risk of lymph node metastasis in BCT group is 2.65 times than in the BCT and RT group (P<0.05). Compared with MRM group, the risk of lymph node metastasis had no significant difference in BCT and RT group (P>0.05).

Compared with modified radical mastectomy, breast conserving surgery combined with radiation therapy for breast cancer can not only recover quickly, reduce the risk of local recurrence, but also ensure a relatively normal breast shape, which is conducive to the improvement of postoperative quality of life and has clinical value.