To investigate the clinical effects of different kinds total thyroidectomy and its influence on parathyroid function.

Retrospective analysis of 86 patients with thyroid papillary carcinoma from January 2014 to January 2017 was performed, the patients were divided into three group according to the method of the surgery. group A (25 cases, underwent routine total thyroidectomy), group B (32 cases, injected with nano-carbon tracers before surgery), group C (29 cases, underwent improved Miccoli surgery). Clinical data were analyzed by using statistical software SPSS 20.0, measurement data such as clinical effects, serum calcium and PTH level were expressed as and were examined by using t test. Count data, such as incidences of mis-resection, hypocalcemia and hypoparathyroidism were examined by using Chi-square test. A P value<0.05 was considered as statistically significant difference.

There was no significant difference between 3 groups in operation time, intraoperative blood loss and number of removed lymph nodes (P>0.05). The mis-resection of parathyroid of the group B, C were significantly lower than that of the group A (P<0.05). The level of serum calcium and PTH of the three groups were significantly decreased (P<0.05). The level of serum calcium and PTH of the group B, C were significantly higher than those of the group A (P<0.05), the incidences of hypocalcemia and hypoparathyroidism of the group B, C were significantly lower than those of the group A (P<0.05).

The improved Miccoli surgery and combined use of nano-carbon for the treatment of thyroid papillary carcinoma is safe and effective with an equal therapeutic effect to that of routine total thyroidectomy, which can protect the parathyroid, reduce the mis-resection rate of parathyroid, as well as the incidences of hypoparathyroidism.