Radical gastrectomy combined with combined organ resection could relieve symptoms, improve quality of life, prolong survival and even cure some locally advanced gastric cancer. Laparoscopic surgery has the advantages, such as minimal trauma, less bleeding and faster postoperative recovery. The experienced center has gradually attempted to apply to combined organ resection for gastric cancer, including combined with splenectomy, pancreatic body and tail, pancreaticoduodenectomy, cholecystectomy, liver resection, hysterectomy and bilateral oophorectomy. Due to technical difficulties, the long learning curve, less number of cases in current studies and the lack of control group, the safety, feasibility and long-term effect of laparoscopic combined combined organ resection for gastric cancer still require high level evidences, therefore more multicenter clinical trials should be performed deeply.