探究腹腔镜急诊切除与支架置入限期切除治疗梗阻性结直肠癌的临床效果。

112例梗阻性结直肠癌患者，依据治疗意愿采用1:1配对法分为观察组（行急诊支架置入后限期腹腔镜切除手术）和对照组（行腹腔镜急诊手术），每组各56例。采用t检验或χ²检验比较两组患者围手术期指标、炎症指标、免疫功能指标、生活质量及并发症发生率。以P<0.05认为差异有统计学意义。

与对照组相比，观察组患者术中出血量明显减少，一期吻合率明显增高，首次排气时间明显缩短，总住院费用明显增高（P<0.05），环周切源阳性率明显降低（P<0.05）。术后两组患者C反应蛋白（CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平明显降低，且术后观察组明显低于对照组（P<0.05）；CD3⁺、CD4⁺、CD4⁺/CD8⁺较治疗前明显降低，但观察组明显高于对照组（P<0.05）。术后两组患者癌症患者生命质量核心量表（EORTC QLQ-C30）中疲乏症状较治疗前明显降低，且观察组低于对照组（P<0.05）；术后两组患者角色功能、躯体功能、整体健康状况评分较治疗前明显升高，且观察组明显高于对照组（P<0.05）。观察组患者并发症总发生率较对照组明显降低（P<0.05）。

急诊支架置入后限期腹腔镜切除手术治疗梗阻性结直肠癌患者能够明显减轻术中创伤，促进患者术后康复，减轻机体炎症反应并保护免疫功能，提高患者生活质量，有效减少并发症的发生。

To explore the clinical efficacy of emergency laparoscopic resection and stent placement versus definitive laparoscopic resection for obstructive colorectal cancer.

112 patients with obstructive colorectal cancer were divided into the observation group (receiving emergency stent placement followed by definitive laparoscopic resection) and the control group (undergoing emergency laparoscopic surgery) by a 1:1 matching method, with 56 patients in each group. t test or χ² test was used to compare the perioperative indicators, inflammatory indicators, immune function indicators, quality of life, and complication rates between the two groups. P<0.05 was considered statistically significant.

Compared with the control group, the observation group had significantly less intraoperative blood loss, significantly higher primary anastomosis rate, significantly shorter first defecation time, significantly higher total hospitalization cost (P<0.05), and significantly lower positive rate of circumferential resection source. Postoperative levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in both groups significantly decreased, and the observation group was significantly lower than the control group (P<0.05); CD3⁺, CD4⁺, and CD4⁺/CD8⁺ were significantly lower than before treatment, but the observation group was significantly higher than the control group (P<0.05). The core quality of life scale (EORTC QLQ-C30) of cancer patients in both groups showed significantly lower fatigue symptoms after surgery, and the observation group was significantly lower than the control group (P<0.05); the scores of role function, physical function, and overall health status after surgery were significantly higher in the observation group than in the control group (P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group (P<0.05).

Emergency stent placement followed by definitive laparoscopic resection for patients with obstructive colorectal cancer can significantly reduce intraoperative trauma, promote postoperative recovery, reduce the body's inflammatory response and protect immune function, improve the quality of life of patients, and effectively reduce the occurrence of complications.