分析甲状腺全切除术患者血清巨噬细胞移动抑制因子（MMIF）联合围手术期相关指标[白介素-6（IL-6）、甲状旁腺激素（PTH）]对术后早期甲状旁腺功能减退的预测价值。

前瞻性选取2021年1月至2025年1月行甲状腺全切除术的130例患者为研究对象，依据术后1个月空腹血钙水平（指离子钙^[1]）分为甲状旁腺功能减退组（n=40，血钙水平<2.1mmol/L）和正常组（n=90，血钙水平≥2.1mmol/L）。以Logistic回归分析构建了以MMIF、IL-6、PTH为变量的联合预测模型，采用受试者工作特征曲线（ROC）分析术后MMIF、IL-6、PTH水平对早期甲状旁腺功能减退的预测价值。

甲状旁腺功能减退组患者术后MMIF、IL-6水平高于正常组，PTH水平低于正常组（P<0.05）。Logistic回归分析显示，术后MMIF、IL-6、PTH是甲状旁腺功能减退的预测指标，联合预测模型为Logit (P)=-4.440+2.178×MMIF+0.189×IL-6-0.257×PTH。ROC曲线显示，MMIF、IL-6、PTH联合预测术后早期甲状旁腺功能减退的曲线下面积（AUC）为0.892，灵敏度为82.5%，特异度为92.2%，联合预测效能优于各指标单独预测（P<0.05）。

甲状腺全切除术患者术后MMIF、IL-6、PTH水平对术后早期甲状旁腺功能减退具有一定的预测价值，且三者联合检测可提高其预测效能。临床上可考虑在术后早期筛查上述指标，及时采取防治措施，以减轻甲状旁腺功能损伤。

To analyze the predictive value of serum macrophage migration inhibitory factor (MMIF) combined with perioperative indicators [interleukin-6 (IL-6), parathyroid hormone (PTH)] for early postoperative hypoparathyroidism in patients undergoing total thyroidectomy.

A prospective study was conducted on 130 patients who underwent total thyroidectomy from January 2021 to January 2025. All patients were followed up postoperatively and divided into the hypoparathyroidism group (n=40, serum calcium level <2.1mmol/L) and the normal group (n=90, serum calcium level ≥2.1mmol/L) based on fasting serum calcium levels (referring to ionized calcium^[1]) at 1 month after surgery. A combined prediction model with MMIF, IL-6, and PTH as variables was constructed using Logistic regression analysis. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of postoperative MMIF, IL-6, and PTH levels for early hypoparathyroidism.

The levels of postoperative MMIF and IL-6 in the hypoparathyroidism group were higher than those in the normal group, while the PTH level was lower (P<0.05). Logistic regression analysis showed that postoperative MMIF, IL-6, and PTH were predictive indicators of hypoparathyroidism, and the combined prediction model was Logit(P) = -4.440 + 2.178 × MMIF + 0.189 × IL-6 - 0.257 × PTH. ROC curve analysis revealed that the area under the curve (AUC) of the combined prediction of early postoperative hypoparathyroidism by MMIF, IL-6, and PTH was 0.892, with a sensitivity of 82.5% and a specificity of 92.2%. The combined prediction efficacy was superior to that of each indicator alone (P<0.05).

Postoperative MMIF, IL-6, and PTH levels in patients undergoing total thyroidectomy have certain predictive value for early postoperative hypoparathyroidism, and the combined detection of the three can improve the predictive efficacy. Clinically, early postoperative screening of these indicators may be considered, and timely prevention and treatment measures can be taken to reduce parathyroid function damage.