分析腹腔巨大间叶源性肿瘤的临床特点、外科治疗及其预后。

回顾性总结自2018年1月至2021年6月57例腹腔巨大间叶源性肿瘤患者的临床资料，分析其病种及人口学特征、术中探查及外科治疗情况、围手术期及随访预后情况等。对于连续型变量进行正态性检验，若满足正态分布，则以均数±标准差表示；若不满足正态分布，则以中位数±四分位数间距表示。对于分类变量，以频数（百分率）表示。所有数据分析与统计用GraphPad Prism 9.0完成。

共纳入57例直径≥10 cm、瘤体≥1 kg的腹腔巨大间叶源性肿瘤，包括间质瘤31例、脂肪肉瘤13例、平滑肌肉瘤2例、横纹肌肉瘤2例、淋巴管瘤2例、神经鞘瘤2例及其他肿瘤5例。发病年龄（55.8±13.9）岁，肿瘤直径（13.0±7.0）cm，手术时长（175.0±90.0）min，术中出血量（200.0±450.0）ml，术中输血率26.3%，多灶率22.8%，整块切除率80.7%，侵犯周围结构率22.8%，联合脏器切除率50.9%，患者术后住院（11.0±5.0）d、随访（23.0±16.0）个月，死亡4例（7.0%），均因肿瘤复发转移死亡。

间质瘤与脂肪肉瘤是最多见的腹腔巨大间叶源性肿瘤，不同类型肿瘤的临床特征与外科治疗存在差异，提高对此类疾病的认识有助于改善此类患者的临床预后。

To summarize the clinical characteristics，surgical management and prognosis of intra-abdominal giant mesenchymal tumors.

Retrospective collection of qualified cases between Jan 2018 and Jun 2021 was performed. Demographics，clinical，surgical and pathological characteristics as well as prognosis were analyzed. Continuous variables with normal distribution were presented as mean ± sd，and Continuous variables with abnormal distribution were presented as median ± IQR.

57 cases with abdominal giant mesenchymal tumors ≥10 cm in diameter and ≥1 kg in size were included，including 31 gastrointestinal stromal tumors，13 liposarcoma，2 leiomyosarcoma，2 rhabdomyosarcoma，2 lymphangioma，2 Schwannoma and the other 5 cases were collected. The on-set age was（55.8±13.9）years old，the diameter of tumor was（13.0±7.0）cm，the overall duration of surgery was（175.0±90.0）min，the intraoperative bleeding was（200.0±450.0）ml，intraoperative blood transfusion rate was 26.3%，the multifocal incidence was 22.8%，the en-bloc resection rate was 80.7%，the tumor invasion rate was 22.8%，the combined organ resection rate was 50.9%，the postoperative hospitalization was（11.0±5.0）d. During the（23.0±16.0）m follow-up period，4 cases（7.0%）deceased from tumor recurrence and metastasis.

Gastrointestinal stromal tumors and liposarcoma were the most common intra-abdominal giant mesenchymal tumors. Different types of tumors have different clinical characteristics and surgical treatment. Improving the understanding of these diseases is helpful to improve the clinical prognosis of these patients.