探讨保留乳房的乳腺癌切除术与改良根治术治疗绝经前乳腺癌患者的效果比较。

选取2009年10月至2012年10月住院治疗的绝经前乳腺癌患者160例进行前瞻性研究，根据手术术式的不同应用随机数字法分为保乳组(80例)和根治组(80例)，其中保乳组采用保留乳房的乳腺癌切除术，根治组采用改良根治术进行治疗。应用SPSS 20.0统计学软件进行统计学处理，术中相关指标及乳腺癌治疗功能评价系统以(±s)表示，采用独立t检验；生存率、局部复发率及远处转移率采用卡方检验，以P<0.05表示差异具有统计学意义。

与根治组相比，保乳组患者的术中出血量显著降低(P<0.05)，手术时间和住院时间显著缩短(P<0.05)；两组患者的2年生存率均为100%，保乳组患者的5年生存率、5年局部复发率和5年远处转移率分别为80例(100.0%)、3例(3.8%)和1例(1.3%)，根治组分别为78例(96.3%)、5例(6.3%)和3例(3.8%)，两组相比，差异均无统计学意义(χ²＝3.057, 0.526, 1.026, P>0.05)；与根治组相比，保乳组患者的FACT－B和生理状况均显著提高(P<0.05)；而两组患者的社会/家庭状况、功能状况、功能状况、情感状况和乳腺癌附加关注相比差异均无统计学意义(P>0.05)。

保留乳房的乳腺癌切除术治疗绝经前乳腺癌患者的临床效果较好，且可显著提高患者的生活质量。

To investigate the effect of the breast conserving surgery and modified radical mastectomy in the treatment of pre-menopausal breast cancer patients.

160 cases of pre-menopausal breast cancer patients treated in our hospital were analyzed from October 2009 to October 2012, a prospective study was conducted according to the different surgical procedures. random numbers methods was used to divide the patients into the breast conserving group and the modified radical group, each 80 cases, the breast conserving group was given breast conserving surgery (BCS), the modified radical group was given modified radical mastectomy (MRM). Statistical analysis were performed by using SPSS 20.0 software, intraoperative relevant indicators and the functional assessment of cancer therapy-breast were presented as and examined by using t test; the survival rate, recurrence rate and distant metastasis rate were presented as [n (%)] and examined by chi square. A P<0.05 was considered as significant difference.

Compared with the modified radical group, the intraoperative blood loss of breast conserving group was significantly decreased (P<0.05), the operation time and hospitalization time significantly was significantly shorten (P<0.05); The 2-year survival rate of the two groups was both 100%, the 5-year survival rate, 5-year recurrence rate and 5-year distant metastasis was 80 cases (100.0%), 3 cases (3.8%) and 1 cases (1.3%) in the breast conserving group and 78 cases (96.3%), 5 cases (6.3%) and 3 cases (3.8%) in the radical group respectively, the difference was not statistically significant (χ²=3.057, 0.526, 1.026, P>0.05). Compared with the radical group, the FACT-B and physical well-being of the breast conserving group were both significantly increased (P<0.05); but the social/family well-being, functional well-being, emotional well-being and additional concerns of the two groups had no statistically significant (P>0.05).

Breast conserving surgery in the treatment of pre-menopausal breast cancer patients has good clinical effect, and can significantly improve the quality of life of patients.