Effect of Laparoscopic Radical Resection via Cranial-Caudal Combined Approach for Right-Sided Colon Cancer Objective To explore the short-and medium-term effects of laparoscopic radical resection via the cranial-caudal combined approach versus the complete cranial approach in the treatment of right-sided colon cancer.

Clinical data of 127 patients with right-sided colon cancer admitted from March 2019 to March 2023 were collected. According to the surgical approach, patients were divided into the combined group (n=65, cranial-caudal combined approach) and the cranial group (n=62, complete cranial approach). Data were analyzed using SPSS 25.0 statistical software. Measurement data conforming to normal distribution were expressed as (±s) and compared by independent sample t test; enumeration data were expressed as cases or percentages and compared by χ² test. A two-tailed test with α=0.05 was used for statistical significance.

Compared with the cranial group, the combined group had shorter operation time, less intraoperative blood loss, more dissected lymph nodes, earlier first extubation time, and shorter hospital stay (P<0.05). After surgery, the serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), and carbohydrate antigen 19-9 (CA19-9) in both groups were lower than those before surgery (P<0.05), but there was no significant difference between the two groups (P>0.05). There were no statistically significant differences in the total incidence of complications within 30 days after surgery or the recurrence rate within 2 years after surgery between the two groups (P>0.05).

Laparoscopic D3 radical resection for right-sided colon cancer via the cranial-caudal combined approach and the complete cranial approach achieves comparable oncological efficacy. However, the cranial-caudal combined approach can increase the number of dissected lymph nodes, shorten operation time and reduce intraoperative blood loss, and enable earlier extubation and hospital discharge.