To evaluate the application effect of laparoscopic complete mesocolic excision (LCME) via the cranial-caudal-middle approach in the treatment of right-sided colon cancer.

A retrospective analysis was conducted on the clinical data of 110 patients with right-sided colon cancer who underwent LCME from November 2021 to November 2024. According to the surgical approach, patients were divided into the combined approach group (n=49, treated with cranial-caudal-middle approach) and the medial approach group (n=52, treated with medial approach). Data were analyzed using SPSS 27.0 statistical software. Measurement data were described as (±s) and compared by t test; enumeration data were described as [cases (%)] and compared by χ² test. P<0.05 was considered statistically significant.

Compared with the medial approach group, the combined approach group had shorter operation time and less intraoperative blood loss (P<0.05); there were no significant differences in postoperative recovery-related indicators between the two groups (P>0.05); the incidence of complications in the combined approach group was lower than that in the medial approach group (P<0.05).

Compared with the medial approach, LCME via the cranial-caudal-middle approach in the treatment of right-sided colon cancer can shorten operation time, reduce intraoperative blood loss and postoperative complications, and has certain advantages in clinical application. Note: "LCME" (laparoscopic complete mesocolic excision) is the standard international abbreviation for laparoscopic complete mesocolic excision, which emphasizes the complete removal of the colonic mesentery along the embryonic fascia plane, consistent with the surgical principle of "complete mesocolic excision (CME)" for colon cancer. The term accurately reflects the surgical technique described in the study.