Abstract:
Objective
To explore the influence of laparoscopic natural orifice transluminal endoscopic surgery (NOSES) on the gastrointestinal function and long-term efficacy of patients with colorectal cancer.
Methods
The clinical data of 102 patients with colorectal cancer from June 2019 to June 2022 were retrospectively analyzed. According to different surgical methods, they were divided into the conventional group (n=62) and the NOSES group (n=40). The conventional group received conventional laparoscopic radical resection of colorectal cancer, and the NOSES group received NOSES treatment. The SPSS 22.0 software was used to analyze the data. Measurement data were expressed as (![]()
), and independent sample t tests were performed; Enumeration data were expressed as［ cases (%)］, and χ2 tests were performed; Rank Sum tests were performed for ranked data. The test criterion was α=0.05.
Results
Compared with the conventional group,the patients in the NOSES group had a longer operation time and less intraoperative blood loss (P<0.05),and the postoperative exhaust time and hospital stay were significantly shortened (P<0.05). At 72 hours after the operation, compared with the conventional group, the levels of serum C-reactive protein (CRP), white blood cell count (WBC), and tumor necrosis factor-α (TNF-α) in the NOSES group were lower (P<0.05),and the levels of motilin and gastrin were higher (P<0.05). There were no statistically significant differences in the total incidence of postoperative complications, the distant metastasis rate and local recurrence rate of tumors within 2 years, and the survival rate of patients between the two groups (P>0.05).
Conclusion
NOSES used in the treatment of colorectal cancer can effectively improve the perioperative indexes, reduce the body's inflammatory response of patients, and promote the recovery of their gastrointestinal function. It has no obvious influence on the long-term recurrence of the disease and tumor metastasis.
Key words:
Colorectal Neoplasms,
Natural Orifice Specimen Extraction Surgery,
Inflammation,
Gastrointestinal Function,
Recurrence
Ke Wang, Yumin Yue, Zhenzhen Wu, Zeyu Xu, Xiaohui Hui, Yun Zhao, Weijia Dou, Qingchuan Zhao. The influence of laparoscopic natural orifice transluminal endoscopic surgery on the intestinal function and long-term efficacy of patients with colorectal cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(04): 413-416.