Abstract:
Objective To investigate the efficacy of extrinsic anatomic liver pedicle technique in the treatment of intrahepatic cholangiocarcinoma (ICC) patients during laparoscopic hepatectomy and its influence on liver function and inflammation.
Methods Clinical data of 116 patients who received extrinsic anatomic pedicle technique for intrahepatic cholangiocarcinoma in our hospital from January 1, 2018 to December 31, 2019 were collected and analyzed. They were divided into extrinsic group (n=58) and intrathecal group (n=58) according to the surgical method, and all patients were followed up for 3 years. The operation duration, intraoperative blood loss, first anal exhaust time, postoperative hospital stay, liver function indexes (ALT, AST, TBIL, ALB), inflammatory factors (CRP, IL-6, TNF-α), complications, and survival during follow-up were compared between the two groups. SPSS 22.0 software was used to analyze the data. The t test was used for inter-group comparison, the χ2 test was used for inter-group comparison and the Log-Rank test was used for survival analysis. P<0.05 indicated that the difference was statistically significant.
Results The operative time, intraoperative blood loss, first anal exhaust time and postoperative hospitalization day in extrinsic group were significantly lower than those in intraoral group (P<0.05). The ALT, AST and TBIL levels in extrasthecal group were significantly lower than those in intrathecal group (P<0.05) at 1, 3 and 7 days after surgery, while the ALB level was significantly higher than that in intrathecal group (P<0.05). The levels of CRP, IL-6 and TNF-α in extrinsic group were significantly lower than those in intrathecal group at 1d, 3d and 7d after surgery (P<0.05). The 1-year survival rate and 3-year survival rate in extrinsic group were significantly higher than those in intrathecal group (P<0.05).
Conclusion In the treatment of ICC patients during laparoscopic hepatectomy, extrinsic anatomical liver stell technique has the advantages of less surgical trauma, less bleeding and faster recovery, which can effectively protect the liver function of patients, reduce inflammation and do not affect the quality of life, and is worthy of clinical promotion and application.
Key words:
Intrahepatic Bile Duct Cell Carcinoma,
Extrinsic Anatomic Liver Pedicle Technique,
Laparoscopic Hepatectomy,
Liver Function,
Inflammatory Response
Jiong Liu, Le Peng, Wei Ma, Bin Jiang. Evaluation of Therapeutic Effect of Glissonean Pedicle Transection Technique in The Treatment of Intrahepatic Cholangiocarcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(04): 373-376.