To investigate the perioperative status and clinical value of laparoscopic subtotal colectomy combined with modified Duhamel in the treatment of adult Hirschsprung's disease.

The data of 25 adult patients with Hirschsprung’s disease who underwent laparoscopic subtotal colon resection combined with modified Duhamel from June 2019 to December 2021 were retrospectively analyzed. SPSS 25.0 software was used for statistical analysis. Count data conforming to normal distribution were described by（

The median age of the 25 patients was 42 years old（18~68 years old），and the median length of hospital stay was 18 days（11~54 days）. Among the 25 patients，1 case had common megacolon and 24 cases had long segmental megacolon. The median operative time was 4.5h（2~7.5 h），and the median intraoperative blood loss was 150 ml（100~600 ml）. The median time of first postoperative activity was 3d（2~6 d），and the mean postoperative fasting time was（4.9±0.3）d. Three patients had perioperative complications，including intestinal obstruction，intestinal fistula，abdominal cavity and sacral tail abscess，etc. Anal function was evaluated at 3 days before surgery，1 month and 3 months after surgery，and the overall good rate was 32%，84% and 96%，respectively.

Laparoscopic colonic subtotal resection combined with modified Duhamel surgery is safe and effective in the treatment of adult Hirschsprung’s disease，and worthy of promotion and application in clinical practice.