This is the first report about Ligation-free radical resection of colon cancer in hepatic flexure with priority dissection of No. 206 and No. 204 lymph nodes. Firstly，LigaSure（LF1937）forceps was used to peel off the right gastroepiploic mesentery with the right hemi-colon and its mesentery from the cranial side to the caudal side，and to expose the right Toldt's fascia plane. Therefore，the anterior fascial plane of the pancreatico-duodenum and the confluence of the Henle trunk into the superior mesenteric vein are revealed clearly. Secondly，the membrane bridge on the surface of the ileo-mesocolon was incised along the infravascular fossa of the ileocolon. The fascial space was extended between the dorsal layer of the right mesocolon and the right Toldt’s fascia，then converged the cranial side of the Toldt’s fascial space. The right mesocolon was peeled off at the right edge of the superior mesenteric artery，and the breakwater technique of LigaSure（LF1937）was applied to coagulate and transect vessels as followed：the ileocolic vessels，the right colic vessels，and the middle colic vessels. Meanwhile，the No.203，No.213 and No.223 groups of lymph nodes are dissected sequentially.