To investigate the predictive value of group 1 innate lymphocyte（ILC1）in the occurrence of immunosuppression in intestinal sepsis.

The clinical data of 20 patients with intestinal sepsis caused by colon perforation from August 2020 to August 2021 were prospectively analyzed and peripheral blood were dropped within 24 hours of admission. Two groups were set according to whether patients were accompanied by immunosuppression（10 cases in the group without immunosuppression vs. 10 cases in the group with immunosuppression）. SPSS 22.0 was used for statistical analysis. Continuous variable data such as age，BMI，lymphocytes Counts and various types of intrinsic lymphocyte ratios are expressed by（

The two groups of patients were comparable in terms of average age，gender composition and BMI，and the difference was not statistically significant. The lymphocyte count of patients with intestinal sepsis accompanied by immunosuppression was significantly lower than that of patients without immunosuppression［（1.6±0.4）vs.（0.6±0.3），P<0.01）］. The proportion of ILC1 innate lymphoid cells among all innate lymphoid cells was significantly up-regulated in the peripheral blood of patients with intestinal sepsis accompanied by immunosuppression［（27.3±6.3）vs.（45.4±6.7），P<0.0001］. By constructing ROC curve，it is found that ILC1 had good sensitivity（90.9%）and specificity（81.8%）for predicting the occurrence of intestinal sepsis immunosuppression when the proportion of all inherent lymphocytes was>32.5%.

The proportion of group 1 innate lymphocytes in all lymphocytes can better predict the occurrence of immunosuppression in intestinal sepsis，has predictive value.