To investigate the safety and short-term clinical outcome of laparoscopic pylorus and vagus nerve-preserving gastrectomy (LAPPG), compared with traditional distal gastrectomy (DG), in treating early gastric cancer.

A retrospective cohort study of 100 patients with early gastric cancer from March 2018 to May 2019 was performed. The patients were divided into LAPPG Group (44 cases) and DG Group (56 cases) . Statistical analysis were performed by using SPSS 23.0 software. Measurement data such as perioperative indicators, gallbladder contraction rate, PG-SGA scale, digestive system disease quality of life index table (Glqi) were expressed as (±s) and were analyzed by using independent t test. Complications were analyzed by using χ² test. A P value of <0.05 is considered as statistically significant difference.

The operation time in the LAPPG group was longer than that in the DG group, while the time of first exhaust and defecation, gastric emptying time, postoperative hospital stay, and intraoperative blood loss were shorter/lower than those in the DG group respectively (P<0.05). Compared with the DG group, there were higher gallbladder contraction rate at 30 min, however lower gallbladder contraction rate at 45min and 60min in the LAPPG group (P<0.05). The PG-SGA score of the LAPPG group was lower than that of the DG group at 6 months after surgery, and the GLQI score was higher than that of the DG group (P<0.05) . The postoperative complication rate of 9.1% in the LAPPG group was lower than 17.9% in the DG group, without statistically significant difference (P>0.05).

Compared with traditional DG, LAPPG is more conducive to improving the gastric emptying function and gallbladder contraction function of patients with early gastric cancer, improving the nutritional status and quality of life, and accelerating the postoperative rehabilitation process, with fewer complications, and it is safe and reliable.