To investigate the feasibility and safety of pancreaticoduodenectomy based on Enhanced Recovery After Surgery (ERAS) principles.

From June 2014 to June 2019, the clinical data of patients underwent pancreaticoduodenectomy were analyzed retrospectively. Among 44 patients, there were 24 cases received perioperative ERAS managements (ERAS group) and 20 cases underwent traditionally perioperative management (traditional group). Statistical analysis were performed by using SPSS19.0 software. Measurement data such as Perioperative indicators and surgical indicators were represented as (±s) and were examined by using independent t test. Postoperative complications were analyzed by using χ² test. A P value of <0.05 was considered as statistical significant difference.

There was no significant difference in terms of intraoperative bleeding and operation time between two groups (P>0.05). There were significant advantages in ERAS group than those in traditional group with higher satisfaction, in terms of the postoperative exhaust time, hospital stay, medical costs, and the pain scores on 24 hours and 48 hours after operation (P<0.05). In ERAS group, there were 5 cases of postoperative complications (20.8%), which was significantly lower than 10 cases (50%) in traditional group (P<0.05).

It is safe and feasible to perform pancreaticoduodenectomy based on enhanced recovery after surgery, principles, with the advantages of low hospitalization cost, faster recovery and less postoperative complications, which is worthy of clinical promotion.