Abstract:
Objective To investigate the relationship between serum 25(OH) vitamin D and liver fibrosis in patients with nonalcoholic fatty liver disease.
Methods The experiment was focused on the autumn population in the same area. From August to October 2017, 120 patients with nonalcoholic fatty liver disease were divided into <-1.455 subgroup according to nonalcoholic fatty liver fibrosis score (NFS). Excluding the liver fibrosis subgroup), -1.75~0.676 subgroup (unsure subgroup), >0.676 subgroup (liver fibrosis subgroup), 50 healthy people with age, gender, and geographical matching were matched for the same physical examination In the control group, serum 25 (OH) vitamin D, CK18 and YKL40 levels were measured by ELISA. SPSS 19.0 statistical software was used for data analysis. Liver fibrosis indexes and serum 25(OH) vitamin D were showed as (±s), compared with independent t test. Multiple date sets were compared with Variance and Spearman correlation analysis, P<0.05 indicated the difference was statistically significant.
Results Serum 25(OH) vitamin D content decreased with the increase of serum liver fibrosis markers CK18 and YKL40 in NFS>0.676 group (P<0.05). There was no correlation between CK18, YKL40 and serum 25(OH) vitamin D in normal group, NFS<-1.455 group and -1.455≤NFS≤0.676 group (P>0.05).
Conclusions Nonalcoholic steatohepatitis has a trend of liver fibrosis, and serum 25(OH) vitamin D is closely related to the progression of liver fibrosis.
Key words:
Hepatitis,
Liver cirrhosis,
Fatty liver,
25-Hydroxyvitamin D2
Likun Fu, Hongmei Cui, Chunyan Zou, Li Li, Jinglong Li, Changshun Xie, Yuemin Nan, Lina Sheng. Correlation between serum 25(OH) vitamin D and liver fibrosis in nonalcoholic fatty liver disease[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(06): 603-605.