To study the efficacy of total laparoscopic radical surgery and open surgery in treatment of primary liver cancer and its influence on dynamic changes of chemokine 12.

The clinical data of 92 patients with primary liver cancer in our hospital from May 2015 to October 2017 were retrospectively analyzed. All the patients were divided into 43 cases of open group (open surgery) and 49 cases of laparoscopic group (total laparoscopic radical surgery) by surgical procedures. SPSS20.0 statistical software was adopted, the measurement data of postoperative recovery, dynamic changes of chemokine 12 before and after surgery were expressed by (±s), and independent t test was adopted; The incidence of postoperative complications was measured by χ² test; P<0.05 was considered statistically significant.

The incidence of postoperative complications, postoperative drainage tube indwelling time, postoperative first feeding time, postoperative hospital stays in laparoscopic group were lower than those in open group (P<0.05); The chemokine 12 expression levels in two groups gradually decreased as postoperative recovery time increased (P<0.05), and the postoperative 1 d, 3 d, 7 d chemokine 12 levels in laparoscopic group were lower than those in open group (P<0.05); There was no statistical difference in the postoperative 7 d chemokine 12 level between laparoscopic group and healthy group (P>0.05).

Total laparoscopic radical surgery in treatment of primary liver cancer is effective, it can achieve low incidence of postoperative complications and quicj postoperative recovery, and the chemokine 12 level quickly decreases.